Ivermectin and moxidectin against soil-transmitted helminth infections

被引：14
作者：
Hurlimann, Eveline [1 ,2 ]
Hofmann, Daniela [1 ,2 ]
Keiser, Jennifer [1 ,2 ]
机构：
[1] Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, Allschwil, Switzerland
[2] Univ Basel, Basel, Switzerland
来源：
TRENDS IN PARASITOLOGY | 2023年 / 39卷 / 04期
基金：
瑞士国家科学基金会;
关键词：
STRONGYLOIDES-STERCORALIS INFECTIONS; TRICHURIS-TRICHIURA; PHARMACOKINETICS; SAFETY; EFFICACY; ALBENDAZOLE; TOLERABILITY; BIOAVAILABILITY; ONCHOCERCIASIS; AVERMECTINS;
D O I：
10.1016/j.pt.2023.01.009
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Ivermectin and moxidectin, two macrocyclic lactones, are potent antiparasitic drugs currently registered and mainly used against filarial diseases; however, their potential value for improved soil-transmitted helminth (STH) control has been acknowledged. This review provides insights on recent studies evaluating the efficacy of ivermectin and moxidectin as single or coadministered therapy against human soil-transmitted helminthiases (including Strongyloides stercoralis infections) and on pharmacokinetic/pharmacodynamic parameters measured in treated populations. Furthermore, we discuss current gaps for research, highlight advantages - but also existing challenges - for uptake of ivermectin and/or moxidectin treatment schemes into routine STH control in endemic countries.
引用
收藏
页码：272 / 284
页数：13
相关论文
共 90 条
[1]   Pharmacokinetic Characterization and Comparative Bioavailability of an Innovative Orodispersible Fixed-Dose Combination of Ivermectin and Albendazole: A Single Dose, Open Label, Sequence Randomized, Crossover Clinical Trial in Healthy Volunteers [J].
Algorta, Jaime ;
Krolewiecki, Alejandro ;
Pinto, Filipe ;
Gold, Silvia ;
Munoz, Jose .
FRONTIERS IN PHARMACOLOGY, 2022, 13
[2]  
[Anonymous], 2013, Assessing the Efficacy of Anthelminthic Drugs against Schistosomiasis and Soil-Transmitted Helminthiasis
[3]   The co-administration of ivermectin and albendazole safety, pharmacokinetics and efficacy against Onchocerca volvulus [J].
Awadzi, K ;
Edwards, G ;
Duke, BOL ;
Opoku, NO ;
Attah, SK ;
Addy, ET ;
Ardrey, AE ;
Quartey, BT .
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 2003, 97 (02) :165-178
[4]   Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections: a randomised, non-inferiority, single-blind trial [J].
Barda, Beatrice ;
Ame, Shaali M. ;
Ali, Said M. ;
Albonico, Marco ;
Puchkov, Maxim ;
Huwyler, Jorg ;
Hattendorf, Jan ;
Keiser, Jennifer .
LANCET INFECTIOUS DISEASES, 2018, 18 (08) :864-873
[5]   Efficacy of Moxidectin Versus Ivermectin Against Strongyloides stercoralis Infections: A Randomized, Controlled Noninferiority Trial [J].
Barda, Beatrice ;
Sayasone, Somphou ;
Phongluxa, Khampheng ;
Xayavong, Syda ;
Keoduangsy, Khonsavanh ;
Odermatt, Peter ;
Puchkov, Maxim ;
Huwyler, Jorg ;
Hattendorf, Jan ;
Keiser, Jennifer .
CLINICAL INFECTIOUS DISEASES, 2017, 65 (02) :276-281
[6]   Toward the 2020 goal of soil-transmitted helminthiasis control and elimination [J].
Becker, Soren L. ;
Liwanag, Harvy Joy ;
Snyder, Jedidiah S. ;
Akogun, Oladele ;
Belizario, Vicente, Jr. ;
Freeman, Matthew C. ;
Gyorkos, Theresa W. ;
Imtiaz, Rubina ;
Keiser, Jennifer ;
Krolewiecki, Alejandro ;
Levecke, Bruno ;
Mwandawiro, Charles ;
Pullan, Rachel L. ;
Addiss, David G. ;
Utzinger, Jurg .
PLOS NEGLECTED TROPICAL DISEASES, 2018, 12 (08)
[7]   Preclinical Study of Single-DoseMoxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model [J].
Bernigaud, Charlotte ;
Fang, Fang ;
Fischer, Katja ;
Lespine, Anne ;
Aho, Ludwig Serge ;
Dreau, Dominique ;
Kelly, Andrew ;
Sutra, Jean-Francois ;
Moreau, Francis ;
Lilin, Thomas ;
Botterel, Francoise ;
Guillot, Jacques ;
Chosidow, Olivier .
PLOS NEGLECTED TROPICAL DISEASES, 2016, 10 (10)
[8]   Alternative treatment strategies to accelerate the elimination of onchocerciasis [J].
Boussinesq, Michel ;
Fobi, Grace ;
Kuesel, Annette C. .
INTERNATIONAL HEALTH, 2018, 10 :i40-i48
[9]   Ivermectin Dosing Strategy to Achieve Equivalent Exposure Coverage in Children and Adults [J].
Brussee, Janneke M. ;
Schulz, Jessica D. ;
Coulibaly, Jean T. ;
Keiser, Jennifer ;
Pfister, Marc .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2019, 106 (03) :661-667
[10]   Multiple-dose versus single-dose ivermectin for Strongyloides stercoralis infection (Strong Treat 1 to 4): a multicentre, open-label, phase 3, randomised controlled superiority trial [J].
Buonfrate, Dora ;
Salas-Coronas, Joaquin ;
Munoz, Jose ;
Trevino Maruri, Begona ;
Rodari, Paola ;
Castelli, Francesco ;
Zammarchi, Lorenzo ;
Bianchi, Leila ;
Gobbi, Federico ;
Cabezas-Fernandez, Teresa ;
Requena-Mendez, Ana ;
Godbole, Gauri ;
Silva, Ronaldo ;
Romero, Marilena ;
Chiodini, Peter L. ;
Bisoffi, Zeno .
LANCET INFECTIOUS DISEASES, 2019, 19 (11) :1181-1190
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