Impact of SARS-CoV-2 exposure history on the T cell and IgG response

被引:30
作者
Keeton, Roanne [1 ,2 ,4 ]
Tincho, Marius B. [1 ,2 ,4 ]
Suzuki, Akiko [1 ,2 ,4 ]
Benede, Ntombi [1 ,2 ,4 ]
Ngomti, Amkele [1 ,2 ,4 ]
Baguma, Richard [1 ,2 ,4 ]
Chauke, Masego, V [1 ,2 ,4 ]
Mennen, Mathilda [3 ,5 ,6 ]
Skelem, Sango [3 ,5 ,6 ]
Adriaanse, Marguerite [3 ,5 ,6 ]
Grifoni, Alba [7 ]
Weiskopf, Daniela [7 ]
Sette, Alessandro [7 ,8 ]
Bekker, Linda -Gail [1 ,3 ,4 ,9 ]
Gray, Glenda [10 ]
Ntusi, Ntobeko A. B. [3 ,4 ,5 ,6 ,11 ]
Burgers, Wendy A. [1 ,2 ,4 ,11 ]
Riou, Catherine [1 ,2 ,4 ,11 ]
机构
[1] Univ Cape Town, Inst Infect Dis & Mol Med, Cape Town, South Africa
[2] Univ Cape Town, Dept Pathol, Div Med Virol, Cape Town, South Africa
[3] Univ Cape Town, Dept Med, Cape Town, South Africa
[4] Groote Schuur Hosp, Cape Town, South Africa
[5] Univ Cape Town, Cape Heart Inst, Fac Hlth Sci, Cape Town, South Africa
[6] Univ Cape Town, South African Med Res Council Extramural Unit Inte, Cape Town, South Africa
[7] La Jolla Inst Immunol, Ctr Infect Dis & Vaccine Res, La Jolla, CA USA
[8] UCSD, Dept Med, Div Infect Dis & Global Publ Hlth, La Jolla, CA USA
[9] Univ Cape Town, Desmond Tutu HIV Ctr, Cape Town, South Africa
[10] South African Med Res Council, Cape Town, South Africa
[11] Univ Cape Town, Wellcome Ctr Infect Dis Res Afr, Cape Town, South Africa
基金
美国国家卫生研究院; 英国惠康基金; 英国医学研究理事会;
关键词
IMMUNITY;
D O I
10.1016/j.xcrm.2022.100898
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposures, from infection or vacci-nation, can potently boost spike antibody responses. Less is known about the impact of repeated exposures on T cell responses. Here, we compare the prevalence and frequency of peripheral SARS-CoV-2-specific T cell and immunoglobulin G (IgG) responses in 190 individuals with complex SARS-CoV-2 exposure histories. As expected, an increasing number of SARS-CoV-2 spike exposures significantly enhances the magnitude of IgG responses, while repeated exposures improve the number of T cell responders but have less impact on SARS-CoV-2 spike-specific T cell frequencies in the circulation. Moreover, we find that the number and nature of exposures (rather than the order of infection and vaccination) shape the spike immune response, with spike-specific CD4 T cells displaying a greater polyfunctional potential following hybrid immu-nity compared with vaccination only. Characterizing adaptive immunity from an evolving viral and immuno-logical landscape may inform vaccine strategies to elicit optimal immunity as the pandemic progress.
引用
收藏
页数:15
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