The association of cortisol/testosterone ratio and sleep quality with coronary heart disease: A case-control study in Chinese rural population

被引：3

作者：

Liu, Huan ^{[1
]}

Huan, Changsheng ^{[1
]}

Nie, Luting ^{[1
]}

Gu, Huiwen ^{[1
]}

Sun, Jiaqi ^{[1
]}

Suo, Xiangying ^{[1
]}

Liu, Daohan ^{[1
]}

Liu, Jingru ^{[1
]}

Wang, Mian ^{[1
]}

Song, Yu ^{[1
]}

Mao, Zhenxing ^{[2
]}

Wang, Chongjian ^{[2
]}

Huo, Wenqian ^{[1
,3
]}

机构：

[1] Zhengzhou Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth, Zhengzhou, Henan, Peoples R China

[2] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, Zhengzhou, Henan, Peoples R China

[3] Dept Occupat & Environm Hlth Sci, 100 Kexue Ave, Zhengzhou 450001, Henan, Peoples R China

来源：

STEROIDS | 2023年 / 193卷

基金：

中国国家自然科学基金;

关键词：

Cortisol; testosterone ratio; Pittsburgh Sleep Quality Index; Coronary heart disease; Combined effect; PROSPECTIVE COHORT; RISK; TESTOSTERONE; DURATION; STRESS; ATHEROSCLEROSIS; SUPPRESSION; ANDROGENS; CORTISOL; HEALTH;

D O I：

10.1016/j.steroids.2023.109197

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purpose: There were limited studies that have probed into the combined effect of the cortisol/testosterone (C/T) ratio as a biomarker of stress and Pittsburgh Sleep Quality Index (PSQI) on coronary heart disease (CHD). This research aimed to explore the association of C/T ratio and PSQI with the risk of CHD in a rural Chinese popu-lation, as well as the interaction and combined effect between C/T ratio and PSQI on CHD. Methods: A case-control study was performed including 307 individuals without CHD and 307 patients drawn from Henan Rural Cohort. Logistic regression was utilized to survey the independent and joint effects of the C/T ratio and PSQI on CHD. To estimate the interaction impact of the C/T ratio and sleep quality (PSQI) on CHD, a cross-product term was introduced in the generalized linear model. Results: Higher C/T ratio and PSQI index scores are related to increased odds ratio for CHD (Odds ratios (ORs) and 95 % confidence interval (CI) were 1.17 (1.07, 1.29), p-trend < 0.001; 1.16 (1.09, 1.22), respectively). The odds ratio of C/T ratio for CHD increased with increasing PSQI in women (pinteraction = 0.018) and total popu-lation (pinteraction = 0.033). The combined group of high C/T ratio and high PSQI had the highest risk of CHD (Total: OR = 7.53, 95 % CI: 4.12-13.76). Conclusions: The risk of CHD was associated with low testosterone levels, high C/T ratios, and high PSQI scores. Additionally, poor sleep quality aggravated the effect of high C/T ratio on coronary heart disease.

引用

页数：7