Nanoparticle-Mediated Hyperthermia and Cytotoxicity Mechanisms in Cancer

被引：15

作者：

Bala, Vanessa-Meletia ^{[1
]}

Lampropoulou, Dimitra Ioanna ^{[2
]}

Grammatikaki, Stamatiki ^{[3
]}

Kouloulias, Vassilios ^{[4
]}

Lagopati, Nefeli ^{[3
]}

Aravantinos, Gerasimos ^{[5
]}

Gazouli, Maria ^{[3
]}

机构：

[1] Hygeia Hosp, Erithrou Stavrou 4, Maroussi 15123, Greece

[2] ECONCARE, Chatzigianni Mexi 5, Athens 11528, Greece

[3] Natl & Kapodistrian Univ Athens, Med Sch, Lab Biol, Athens 11527, Greece

[4] Attikon Univ Hosp, Natl & Kapodistrian Univ Athens, Med Sch, Dept Radiol 2,Radiat Oncol Unit, Athens 11527, Greece

[5] Euroclinic, Athanasiadou 7-9, Athens 11521, Greece

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 01期

关键词：

cancer; hyperthermia; nanoparticles; cytotoxicity mechanisms; DRUG-DELIVERY SYSTEM; GOLD NANOPARTICLES; THERAPY; ULTRASOUND; RELEASE; EXPRESSION; LIPOSOMES; CHEMOTHERAPY; APOPTOSIS; EFFICACY;

D O I：

10.3390/ijms25010296

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hyperthermia has the potential to damage cancerous tissue by increasing the body temperature. However, targeting cancer cells whilst protecting the surrounding tissues is often challenging, especially when implemented in clinical practice. In this direction, there are data showing that the combination of nanotechnology and hyperthermia offers more successful penetration of nanoparticles in the tumor environment, thus allowing targeted hyperthermia in the region of interest. At the same time, unlike radiotherapy, the use of non-ionizing radiation makes hyperthermia an attractive therapeutic option. This review summarizes the existing literature regarding the use of hyperthermia and nanoparticles in cancer, with a focus on nanoparticle-induced cytotoxicity mechanisms.

引用

页数：19

共 124 条

[51] NIR Laser-Responsive PNIPAM and Gold Nanorod Composites for the Engineering of Thermally Reactive Drug Delivery Nanomedicine [J].

Kwon, Yejin ;

Choi, Yonghyun ;

Jang, Jaehee ;

Yoon, Semi ;

Choi, Jonghoon .

PHARMACEUTICS, 2020, 12 (03)

[52] Smart Modification on Magnetic Nanoparticles Dramatically Enhances Their Therapeutic Properties [J].

Lafuente-Gomez, Nuria ;

Milan-Rois, Paula ;

Garcia-Soriano, David ;

Luengo, Yurena ;

Cordani, Marco ;

Alarcon-Iniesta, Hernan ;

Salas, Gorka ;

Somoza, Alvaro .

CANCERS, 2021, 13 (16)

[53] Polydopamine-coated mesoporous silica nanoparticles for multi-responsive drug delivery and combined chemo-photothermal therapy [J].

Lei, Wei ;

Sun, Changshan ;

Jiang, Tongying ;

Gao, Yikun ;

Yang, Yang ;

Zhao, Qinfu ;

Wang, Siling .

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2019, 105

[54]

LEUNIG M, 1992, CANCER RES, V52, P487

[55] Photothermal-Triggered Controlled Drug Release from Mesoporous Silica Nanoparticles Based on Base-Pairing Rules [J].

Li, Xiaoting ;

Wang, Xinhui ;

Hua, Mingli ;

Yu, Haohan ;

Wei, Shaohua ;

Wang, Ao ;

Zhou, Jiahong .

ACS BIOMATERIALS SCIENCE & ENGINEERING, 2019, 5 (05) :2399-2408

[56] A Visible- and NIR-Light Responsive Photothermal Therapy Agent by Chirality-Dependent MoO3-x Nanoparticles [J].

Li, Yiwen ;

Miao, Ziwei ;

Shang, Zhengwen ;

Cai, Ying ;

Cheng, Jiaji ;

Xu, Xiaoqian .

ADVANCED FUNCTIONAL MATERIALS, 2020, 30 (04)

[57] Change in expression of apoptosis genes after hyperthermia, chemotherapy and radiotherapy in human colon cancer transplanted into nude mice [J].

Liang, Han ;

Zhan, Hong-Jie ;

Wang, Bao-Gui ;

Pan, Yuan ;

Hao, Xi-Shan .

WORLD JOURNAL OF GASTROENTEROLOGY, 2007, 13 (32) :4365-4371

[58] Nanohybrid Liposomal Cerasomes with Good Physiological Stability and Rapid Temperature Responsiveness for High Intensity Focused Ultrasound Triggered Local Chemotherapy of Cancer [J].

Liang, Xiaolong ;

Gao, Jing ;

Jiang, Lingdong ;

Luo, Jianwen ;

Jing, Lijia ;

Li, Xiaoda ;

Jin, Yushen ;

Dai, Zhifei .

ACS NANO, 2015, 9 (02) :1280-1293

[59] A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives [J].

Liu, Peng ;

Chen, Guiliang ;

Zhang, Jingchen .

MOLECULES, 2022, 27 (04)

[60] Dual drug delivery system of photothermal-sensitive carboxymethyl chitosan nanosphere for photothermal-chemotherapy [J].

Liu, Xianwu ;

He, Zuyu ;

Chen, Yu ;

Zhou, Chuang ;

Wang, Chao ;

Liu, Yunhao ;

Feng, Changgen ;

Yang, Ziming ;

Li, Puwang .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 163 :156-166

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