Novel Approaches in the Systemic Management of High-Risk Prostate Cancer

被引：4

作者：

Gomez-Aparicio, Maria Antonia ^{[1
]}

Lopez-Campos, Fernando ^{[2
]}

Lozano, Antonio Jose ^{[3
]}

Maldonado, Xavier ^{[4
]}

Caballero, Begona ^{[5
]}

Zafra, Juan ^{[6
]}

Suarez, Vladamir ^{[7
]}

Moreno, Elena ^{[8
]}

Arcangeli, Stefano ^{[9
]}

Scorsetti, Marta ^{[10
]}

Counago, Felipe ^{[8
,11
,12
]}

机构：

[1] Hosp Univ Toledo, Dept Radiat Oncol, Toledo, Spain

[2] Hosp Univ Ramon y Cajal, Dept Radiat Oncol, Ctra Colmenar Viejo, Madrid 28034, Spain

[3] Hosp Univ Virgen Arrixaca, Dept Radiat Oncol, Murcia, Spain

[4] Hosp Valle De Hebron, Dept Radiat Oncol, Barcelona, Spain

[5] Hosp Univ Fuenlabrada, Dept Radiat Oncol, Fuenlabrada, Spain

[6] Hosp Virgen Victoria, Dept Radiat Oncol, Malaga, Spain

[7] GenesisCare Malaga, Dept Radiat Oncol, Malaga, Spain

[8] GenesisCare Madrid, Dept Radiat Oncol, Madrid, Spain

[9] Univ Milan, Dept Radiat Oncol, Bicocca, Italy

[10] IRCCS Humanitas Res Hosp, Radiotherapy & Radiosurg Dept, Milan, Italy

[11] Hosp San Francisco Asis, Dept Radiat Oncol, Madrid, Spain

[12] Hosp Vithas La Milagrosa, Natl Chair Res & Clin Trials, GenesisCare, Madrid, Spain

来源：

CLINICAL GENITOURINARY CANCER | 2023年 / 21卷 / 06期

关键词：

Biomarkers; Systemic treatment; Second-generation antiandrogens; prostate; ANDROGEN-DEPRIVATION THERAPY; NEOADJUVANT HORMONE-THERAPY; BEAM RADIATION-THERAPY; LYMPH-NODE DISSECTION; PHASE-III TRIAL; RADICAL PROSTATECTOMY; SHORT-TERM; ABIRATERONE ACETATE; FOLLOW-UP; DOUBLE-BLIND;

D O I：

10.1016/j.clgc.2023.06.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Locally advanced prostate cancer comprises approximately 20% of new prostate cancer diagnoses. For these patients, international guidelines recommend treatment with radiotherapy (RT) to the prostate in combination with long-term (2-3 years) androgen deprivation therapy (ADT), or radical prostatectomy in combination with extended pelvic lymph node dissection (PLND) as another treatment option for selected patients as part of multimodal therapy. Improvements in overall survival with docetaxel or an androgen receptor signaling inhibitor have been achieved in patients with metastatic castration sensitive or castration resistant prostate cancer. However, the role of systemic therapy combinations for high risk and/or unfavorable prostate cancer is unclear. In this context, the aim of this review is to assess the current evidence for systemic treatment combinations as part of primary definitive therapy in patients with high-risk localized prostate cancer.

引用

页码：E485 / E494

页数：10

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