The role of dysregulated ghrelin/LEAP-2 balance in anorexia nervosa

被引：4
|
作者：
du Montcel, Chloe Tezenas [1 ,2 ]
Duriez, Philibert [1 ,2 ]
Cao, Jingxian [1 ]
Lebrun, Nicolas [1 ]
Ramoz, Nicolas [1 ]
Viltart, Odile [1 ,3 ]
Gorwood, Philip [1 ,2 ]
Tolle, Virginie [1 ]
机构：
[1] Univ Paris Cite, Inst Psychiat & Neurosci Paris IPNP, INSERM, UMR S 1266, F-75014 Paris, France
[2] Hop Sainte Anne, Clin Malad Mentales & Encephale, GHU Paris Psychiat & Neurosci, F-75014 Paris, France
[3] Univ Lille, CNRS, UMR 9193, SCALab Sci Cognit & Sci Affect,PsySEF Dept, F-59000 Lille, France
来源：
ISCIENCE | 2023年 / 26卷 / 11期
关键词：
SECRETION; PEPTIDE; SURVIVAL; BEHAVIOR; REWARD; LEAP2; GH;
D O I：
10.1016/j.isci.2023.107996
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
LEAP-2 is a ghrelin antagonist with an anorexigenic drive. This study investigates the evolution of plasma ghrelin and LEAP-2 concentrations in 29 patients with anorexia nervosa (AN) before and after refeeding and compares it to physiological adaptations during fasting in healthy controls or to mouse model of chronic food restriction and refeeding. Acute and chronic food restriction decrease LEAP-2 and increase ghrelin concentrations in both humans and mice, while patients with AN displayed higher ghrelin and LEAP-2 concentrations before than after refeeding (p = 0.043). After 6 months follow-up, patients with unstable weight gain (n = 17) had significantly decreased LEAP-2 concentrations after refeeding (p = 0.044), in contrast to patients with stable weight gain (n = 12). We provide evidence that the ghrelin/ LEAP-2 system is not regulated according to the nutritional status in AN, in contrast to what is physiolog-ically expected when coping with food restriction.
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页数：12
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