Epigenetics in Eye Development and Ocular Disorders: A Brief Review

被引：2
作者：
Kuchay, Raja Amir Hassan [1 ,3 ]
Hassan, Asima [2 ]
Mir, Yaser Rafiq [1 ]
机构：
[1] Baba Ghulam Shah Badshah Univ, Dept Biotechnol, Rajouri, Jammu & Kashmir, India
[2] Dept Hlth & Med Educ, Srinagar, Jammu & Kashmir, India
[3] Baba Ghulam Shah Badshah Univ, Dept Biotechnol, Rajouri 185234, Jammu & Kashmir, India
来源：
CURRENT MOLECULAR MEDICINE | 2023年 / 23卷 / 09期
关键词：
Ocular disorders; epigenetics; eye development; chromatin; methylation; histones; MESSENGER-RNA EXPRESSION; RETINAL PROGENITOR CELLS; DNA METHYLATION; HISTONE MODIFICATIONS; GENE-EXPRESSION; VERTEBRATE EYE; MECHANISMS; FAMILY;
D O I：
10.2174/1566524023666221003102857
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Epigenetics is a powerful regulator of gene expression. With advanced discoveries in underlying molecular mechanisms that can alter chromatin response to internal and external signals, epigenetic alterations have been implicated in various developmental pathways and human disorders. The extent to which this epigenetic effect contributes to eye development and progression of ocular disorders is currently less defined. However, emerging evidence suggests that epigenetic changes are relevant in the development of eye and ocular disorders like pterygium, age-related macular degeneration, glaucoma and more. This brief review will discuss the relevance of epigenetic mechanisms like DNA methylation, histone modifications, polycomb proteins and noncoding RNAs in the context of eye development and selected ocular disorders.
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收藏
页码：843 / 848
页数：6
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