Prognostic value of tumor necrosis based on the evaluation of frequency in invasive breast cancer

被引：10

作者：

Chen, Jianhua ^{[1
,2
]}

Li, Zhijun ^{[1
]}

Han, Zhonghua ^{[3
]}

Kang, Deyong ^{[4
]}

Ma, Jianli ^{[5
]}

Yi, Yu ^{[1
]}

Fu, Fangmeng ^{[3
]}

Guo, Wenhui ^{[3
]}

Zheng, Liqin ^{[1
]}

Xi, Gangqin ^{[1
]}

He, Jiajia ^{[1
]}

Qiu, Lida ^{[1
,6
]}

Li, Lianhuang ^{[1
]}

Zhang, Qingyuan ^{[7
]}

Wang, Chuan ^{[3
]}

Chen, Jianxin ^{[1
]}

机构：

[1] Fujian Normal Univ, Coll Photon & Elect Engn, Fujian Prov Key Lab Photon Technol, Key Lab OptoElect Sci & Technol Med,Minist Educ, Fuzhou 350117, Peoples R China

[2] Fujian Normal Univ, Coll Life Sci, Fuzhou 350117, Peoples R China

[3] Fujian Med Univ Union Hosp, Dept Breast Surg, Fuzhou 350001, Peoples R China

[4] Fujian Med Univ Union Hosp, Dept Pathol, Fuzhou 350001, Peoples R China

[5] Harbin Med Univ, Canc Hosp, Dept Radiat Oncol, Harbin 150081, Peoples R China

[6] Minjiang Univ, Coll Phys & Elect Informat Engn, Fuzhou 350108, Peoples R China

[7] Harbin Med Univ, Canc Hosp, Dept Med Oncol, Harbin 150081, Peoples R China

来源：

BMC CANCER | 2023年 / 23卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Frequency; Invasive breast cancer; Multiphoton imaging; Tumor necrosis; Spatial heterogeneity; Prognosis; CELL CARCINOMA; FLUORESCENCE; RECURRENCE; ANGIOGENESIS; MICROSCOPY; INDICATOR; COLLAGEN; SCORE; RISK; VALIDATION;

D O I：

10.1186/s12885-023-10943-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundTumor necrosis (TN) was associated with poor prognosis. However, the traditional classification of TN ignored spatial intratumor heterogeneity, which may be associated with important prognosis. The purpose of this study was to propose a new method to reveal the hidden prognostic value of spatial heterogeneity of TN in invasive breast cancer (IBC).MethodsMultiphoton microscopy (MPM) was used to obtain multiphoton images from 471 patients. According to the relative spatial positions of TN, tumor cells, collagen fibers and myoepithelium, four spatial heterogeneities of TN (TN1-4) were defined. Based on the frequency of individual TN, TN-score was obtained to investigate the prognostic value of TN.ResultsPatients with high-risk TN had worse 5-year disease-free survival (DFS) than patients with no necrosis (32.5% vs. 64.7%; P < 0.0001 in training set; 45.8% vs. 70.8%; P = 0.017 in validation set), while patients with low-risk TN had a 5-year DFS comparable to patients with no necrosis (60.0% vs. 64.7%; P = 0.497 in training set; 59.8% vs. 70.8%; P = 0.121 in validation set). Furthermore, high-risk TN "up-staged" the patients with IBC. Patients with high-risk TN and stage I tumors had a 5-year DFS comparable to patients with stage II tumors (55.6% vs. 62.0%; P = 0.565 in training set; 62.5% vs. 66.3%; P = 0.856 in validation set), as well as patients with high-risk TN and stage II tumors had a 5-year DFS comparable to patients with stage III tumors (33.3% vs. 24.6%; P = 0.271 in training set; 44.4% vs. 39.3%; P = 0.519 in validation set).ConclusionsTN-score was an independent prognostic factor for 5-year DFS. Only high-risk TN was associated with poor prognosis. High-risk TN "up-staged" the patients with IBC. Incorporating TN-score into staging category could improve its performance to stratify patients.

引用

页数：14

共 52 条

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