Chemical profile and cytotoxic evaluation of aerial parts of Euphorbia tirucalli L. on gastric adenocarcinoma (AGS cells)

被引：6
|
作者：
de Souza, Larissa Silva [1 ]
Luz Tosta, Cristina [1 ]
Pereira de Oliveira Borlot, Jessica Rodrigues [2 ]
Varricchio, Marcia C. B. N. [3 ]
Kitagawa, Rodrigo Rezende [2 ]
Filgueiras, Paulo Roberto [1 ]
Kuster, Ricardo Machado [1 ]
机构：
[1] Univ Fed Espirito Santo, Dept Chem, Vitoria, ES, Brazil
[2] Univ Fed Espirito Santo, Dept Pharmaceut Sci, Vitoria, ES, Brazil
[3] Petropolis Fac Med, Dept Internal Med, Petropolis, RJ, Brazil
来源：
NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 24期
关键词：
E; tirucalli; stem; latex; triterpenes; cytotoxicity; CANCER CELLS; TRITERPENE;
D O I：
10.1080/14786419.2023.2179623
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Ethanol extract from the aerial parts of Euphorbia tirucalli L. as well as the latex of the plant suspended in water are used by the Brazilian population for the treatment of various diseases, including cancer. The purposes of this study were to determine if the ethanol extract is effective as cytotoxic agent against gastric adenocarcinoma cells (AGS) and its chemical composition by GC-MS, ESI-(-)-FT-ICR MS and (-)-ESI-LTQ-MS/MS. The results were compared with that of latex previously described by us. Hexane and aqueous fractions showed higher cytotoxicity on AGS cells. Nine triterpene compounds were detected by GC-MS in hexane fraction, including euphol and friedelin, while ellagic acid was identified as main phenolic compound in aqueous extract. Therefore, the greater cytotoxic activity of the ethanol extract of the aerial parts of Euphorbia tirucalli for gastric cancer, when compared to latex, seems to originate from the antiproliferative effects of ellagic acid and triterpenes.
引用
收藏
页码：4267 / 4273
页数：7
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