Chemical profile and cytotoxic evaluation of aerial parts of Euphorbia tirucalli L. on gastric adenocarcinoma (AGS cells)

被引：6
|
作者：
de Souza, Larissa Silva [1 ]
Luz Tosta, Cristina [1 ]
Pereira de Oliveira Borlot, Jessica Rodrigues [2 ]
Varricchio, Marcia C. B. N. [3 ]
Kitagawa, Rodrigo Rezende [2 ]
Filgueiras, Paulo Roberto [1 ]
Kuster, Ricardo Machado [1 ]
机构：
[1] Univ Fed Espirito Santo, Dept Chem, Vitoria, ES, Brazil
[2] Univ Fed Espirito Santo, Dept Pharmaceut Sci, Vitoria, ES, Brazil
[3] Petropolis Fac Med, Dept Internal Med, Petropolis, RJ, Brazil
来源：
NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 24期
关键词：
E; tirucalli; stem; latex; triterpenes; cytotoxicity; CANCER CELLS; TRITERPENE;
D O I：
10.1080/14786419.2023.2179623
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Ethanol extract from the aerial parts of Euphorbia tirucalli L. as well as the latex of the plant suspended in water are used by the Brazilian population for the treatment of various diseases, including cancer. The purposes of this study were to determine if the ethanol extract is effective as cytotoxic agent against gastric adenocarcinoma cells (AGS) and its chemical composition by GC-MS, ESI-(-)-FT-ICR MS and (-)-ESI-LTQ-MS/MS. The results were compared with that of latex previously described by us. Hexane and aqueous fractions showed higher cytotoxicity on AGS cells. Nine triterpene compounds were detected by GC-MS in hexane fraction, including euphol and friedelin, while ellagic acid was identified as main phenolic compound in aqueous extract. Therefore, the greater cytotoxic activity of the ethanol extract of the aerial parts of Euphorbia tirucalli for gastric cancer, when compared to latex, seems to originate from the antiproliferative effects of ellagic acid and triterpenes.
引用
收藏
页码：4267 / 4273
页数：7
相关论文
共 50 条
  • [31] Evaluation of the phenolic content in the aerial parts of different varieties of Cichorium intybus L.
    Innocenti, M
    Gallori, S
    Giaccherini, C
    Ieri, F
    Vincieri, FF
    Mulinacci, N
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2005, 53 (16) : 6497 - 6502
  • [32] Chemical Profile and Biological Properties of Methanolic and Ethanolic Extracts from the Aerial Parts of Inula britannica L. Growing in Central Asia
    Ibadullayeva, Aktolkyn K.
    Kasela, Martyna
    Kozhanova, Kaldanay K.
    Kadyrbayeva, Gulnara M.
    Widelski, Jaroslaw
    Wojtanowski, Krzysztof
    Jozefczyk, Aleksandra
    Susniak, Katarzyna
    Okinczyc, Piotr
    Tleubayeva, Meruyert I.
    Karaubayeva, Aigerim A.
    Zhandabayeva, Moldir A.
    Mukhamedsadykova, Aigerim Z.
    Malm, Anna
    MOLECULES, 2024, 29 (23):
  • [33] New Alkyl Phloroglucinol Derivatives from Rhus trichocarpa Roots and Their Cytotoxic Effects on Human Gastric Adenocarcinoma AGS Cells
    Lee, Ki Yong
    Choi, Ji Hoon
    Kim, HyeonWoo
    Yan, Xi-Tao
    Shin, Hyeji
    Jeon, Young Ho
    Sung, Sang Hyun
    PLANTA MEDICA, 2016, 82 (07) : 645 - 649
  • [34] Chemical Composition of Essential Oil of Aerial Parts of Cichorium intybus L. from Iran
    Haghi, Ghasem
    Arshi, Ruhollah
    Ghazian, Fatemeh
    Hosseini, Hossein
    JOURNAL OF ESSENTIAL OIL BEARING PLANTS, 2012, 15 (02) : 213 - 216
  • [35] Chemical composition of the essential oils of Rubia tinctorum L. aerial parts from Iran
    Navaei, Mehrdokht Najafpour
    Mirza, Mehdi
    Dini, Mohammad
    FLAVOUR AND FRAGRANCE JOURNAL, 2006, 21 (03) : 519 - 520
  • [36] Chemical investigation of the aerial parts of Zingiber zerumbet (L.) Sm. from vicinam
    1600, Allured Publishing Company, Carol Stream, IL, USA (07):
  • [37] New flavonol glycoside from Scabiosa prolifera L. aerial parts with in vitro antioxidant and cytotoxic activities
    Al-Qudah, Mahmoud A.
    Otoom, Noor K.
    Al-Jaber, Hala I.
    Saleh, Ayman M.
    Abu Zarga, Musa H.
    Afifi, Fatma U.
    Abu Orabi, Sultan T.
    NATURAL PRODUCT RESEARCH, 2017, 31 (24) : 2865 - 2874
  • [38] New quinones, a sesquiterpene and phenol compounds with cytotoxic activity from the aerial parts of Morinda umbellata L.
    Li, Changkang
    Wang, Hongqing
    Dong, Chaoxuan
    Xie, Jun
    Lai, Shengtian
    Liu, Jianbo
    Chen, Ruoyun
    Kang, Jie
    FITOTERAPIA, 2022, 156
  • [39] Cytotoxic and genotoxic effects of ethanolic extract of Euphorbia hyssoptfolia L. on HepG2 cells
    Araujo, Silvany de Sousa
    Casimiro Fernandes, Thais Cristina
    Cardona, Yaliana Tafurt
    de Almeida, Pedro Marcos
    Mann-Morales, Maria Aparecida
    dos Santos, Andrea Vidal
    Randau, Karina Perrelli
    Benko-Iseppon, Ana Maria
    Brasileiro-Vidal, Ana Christina
    JOURNAL OF ETHNOPHARMACOLOGY, 2015, 170 : 16 - 19
  • [40] Clastogenic and cytotoxic effects of aerial parts' aqueous extract of Synedrella nodiflora (L.) Gaertn. on Wistar rat bone marrow cells
    Chatterjee, Saumabha
    Ray, Sanjib
    CARYOLOGIA, 2019, 72 (03) : 87 - 95
12345