A visible-light-induced photosensitizer-free decarbonylative Minisci-type reaction

This study presents a green and practical visible-light-induced photosensitizer-free decarbonylative Minisci-type reaction using aldehydes as alkyl radical precursors. The photocatalytic system exhibits a broad substrate scope and synthetically useful yields. Mechanistic experiments revealed that alkyl radicals could be generated through auto-oxidation of aldehydes under irradiation, which is a mild and effective method for achieving late-stage functionalization of N-heteroarenes. Some biologically active N-heteroarenes could be alkylated using this photocatalytic system smoothly. A photoinduced photosensitizer-free Minisci-type reaction using aldehydes as radical precursors was reported, which showed excellent yields and functional groups tolerance. This effective method could achieve alkylation of natural products smoothly.