Hypothalamic SEL1L-HRD1 ER-Associated Degradation Is Indispensable for Leptin Signaling in Diet-Induced Obesity by Degrading Misfolded Leptin Receptor

被引:0
作者
Mao, Hancheng
Qi, Ling
机构
关键词
D O I
10.2337/db23-1528-P
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1528-P
引用
收藏
页数:2
相关论文
共 50 条
  • [21] SEL1L-HRD1 ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION IS REQUIRED TO MAINTAIN PANCREATIC ISLET αLPHA CELL MASS AND FUNCTION
    Reinert, Rachel
    JOURNAL OF INVESTIGATIVE MEDICINE, 2022, 70 (07) : 1579 - 1579
  • [22] Enhanced orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity
    Funato, Hiromasa
    Tsai, Allen L.
    Willie, Jon T.
    Kisanuki, Yasushi
    Williams, S. Clay
    Sakurai, Takeshi
    Yanagisawa, Masashi
    CELL METABOLISM, 2009, 9 (01) : 64 - 76
  • [23] Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation
    Kaneko, M
    Ishiguro, M
    Niinuma, Y
    Uesugi, M
    Nomura, Y
    FEBS LETTERS, 2002, 532 (1-2) : 147 - 152
  • [24] Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Regulates PC2 Function and Proglucagon Processing in Islet α-Cells
    Reinert, Rachel B.
    Zhu, Wenzhen
    Pan, Linxiu
    Russo, Anna Chiara
    Ray, Rohit
    Shrestha, Neha
    Lindberg, Iris
    Qi, Ling
    DIABETES, 2023, 72
  • [25] The ER-Associated Degradation Adaptor Protein Sel1L Regulates LPL Secretion and Lipid Metabolism
    Sha, Haibo
    Sun, Shengyi
    Francisco, Adam B.
    Ehrhardt, Nicole
    Xue, Zhen
    Liu, Lei
    Lawrence, Peter
    Mattijssen, Frits
    Guber, Robert D.
    Panhwar, Muhammad S.
    Brenna, J. Thomas
    Shi, Hang
    Xue, Bingzhong
    Kersten, Sander
    Bensadoun, Andre
    Peterfy, Miklos
    Long, Qiaoming
    Qi, Ling
    CELL METABOLISM, 2014, 20 (03) : 458 - 470
  • [26] Reduced Intestinal Absorption of Dipeptides via PepT1 in Mice with Diet-induced Obesity Is Associated with Leptin Receptor Down-regulation
    Hindlet, Patrick
    Bado, Andre
    Kamenicky, Peter
    Delomenie, Claudine
    Bourasset, Fanchon
    Nazaret, Corinne
    Farinotti, Robert
    Buyse, Marion
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (11) : 6801 - 6808
  • [27] Nutritional regulation of hypothalamic leptin receptor gene expression is defective in diet-induced obesity (vol 14, pg 887, 2002)
    Sahu, A
    Nguyen, L
    O'Doherty, RM
    JOURNAL OF NEUROENDOCRINOLOGY, 2003, 15 (01) : 104 - 104
  • [28] Purkinje cell-specific deficiency in SEL1L-hrd1 endoplasmic reticulum-associated degradation causes progressive cerebellar ataxia in mice
    Torres, Mauricio
    Pederson, Brent
    Wang, Hui
    Lin, Liangguang Leo
    Wang, Huilun Helen
    Bugarin-Lapuz, Amara
    Zhao, Zhen
    Qi, Ling
    JCI INSIGHT, 2024, 9 (21)
  • [29] The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity
    Cota, Daniela
    Matter, Emily K.
    Woods, Stephen C.
    Seeley, Randy J.
    JOURNAL OF NEUROSCIENCE, 2008, 28 (28) : 7202 - 7208
  • [30] SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool
    Ji, Yewei
    Luo, Yuan
    Wu, Yating
    Sun, Yao
    Zhao, Lianfeng
    Xue, Zhen
    Sun, Mengqi
    Wei, Xiaoqiong
    He, Zinan
    Wu, Shuangcheng Alivia
    Lin, Liangguang Leo
    Lu, You
    Chang, Lei
    Chen, Fei
    Chen, Siyu
    Qian, Wei
    Xu, Xiaoxi
    Chen, Shengnuo
    Pan, Dongli
    Zhou, Zhangsen
    Xia, Sheng
    Hu, Chih-Chi Andrew
    Liang, Tingbo
    Qi, Ling
    NATURE CELL BIOLOGY, 2023, 25 (05) : 726 - 739