Clinical Characteristics and Tear Film Biomarkers in Patients With Chronic Dry Eye Disease After Femtosecond Laser-Assisted Laser in Situ Keratomileusis

被引：3

作者：

Zhao, Lu ^{[1
]}

Zhang, Yu ^{[1
]}

Duan, Hongyu ^{[1
]}

Yang, Tingting ^{[2
]}

Zhou, Yifan ^{[1
]}

Ma, Baikai ^{[1
]}

Chen, Yueguo ^{[1
,3
]}

Qi, Hong ^{[1
,3
]}

机构：

[1] Peking Univ Third Hosp, Dept Ophthalmol, Beijing Key Lab Restorat Damaged Ocular Nerve, Beijing, Peoples R China

[2] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Ophthalmol, Guangzhou, Guangdong, Peoples R China

[3] Peking Univ Third Hosp, Dept Ophthalmol, Beijing Key Lab Restorat Damaged Ocular Nerve, 49 North Garden Rd, Beijing 100191, Peoples R China

来源：

JOURNAL OF REFRACTIVE SURGERY | 2023年 / 39卷 / 08期

基金：

中国国家自然科学基金;

关键词：

SUBSTANCE-P; GM-CSF; REFRACTIVE SURGERY; CYTOKINE PROFILES; T-CELLS; CORNEAL; TH17; AUTOIMMUNITY; INFLAMMATION; OXYTOCIN;

D O I：

10.3928/1081597X-20230717-02

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE: To investigate clinical characteristics and tear film biomarkers of patients with chronic dry eye disease (DED) fol-lowing femtosecond laser-assisted laser in situ keratomileu-sis (FS-LASIK).METHODS: Patients were divided into the chronic DED after FS-LASIK (n = 36), DED without FS-LASIK (n = 39), and nor-mal control (without FS-LASIK; n = 34) groups. Dry eye, pain, and psychological-related symptoms were evaluated using the Ocular Surface Disease Index (OSDI), Numerical Rating Scale (NRS), Neuropathic Pain Symptom Inventory Modified for the Eye (NPSI-Eye), and Hamilton Anxiety Rating Scale (HAMA) questionnaires. Ocular surface parameters, tear cytokines, and neuropeptide concentrations were evaluated with specific tests.RESULTS: The DED after FS-LASIK group showed higher cor-neal fluorescein staining scores, but lower OSDI and NPSI- Eye scores than the DED without FS-LASIK group (all P < .05). Corneal sensitivity and nerve density decreased in the DED after FS-LASIK group (all P < .01). Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-17A, IL-23, alpha-melanocyte stimulating hormone (a-MSH), oxy-tocin, and substance P levels were highest in the DED after FS-LASIK group, followed by the DED without FS-LASIK and normal control groups (all P < .05). Interferon -g and neuro-tensin levels were only significantly higher in the DED after FS-LASIK group (all P < .05).CONCLUSIONS: Patients with chronic DED after FS-LASIK showed milder ocular symptoms, greater epithelial damage, and higher levels of tear inflammatory cytokines and neuro-peptides than patients with DED without FS-LASIK, indicating that the nervous and immune systems may play significant roles in FS-LASIK-related chronic DED development.

引用

页码：556 / +

页数：12

共 54 条

[1] Corneal Inflammation Following Corneal Photoablative Refractive Surgery With Excimer Laser [J].