Studies on Synthesis, Characterization and Biological Activities of Novel Schiff Bases from amino acridone

被引:0
作者
Habeeb, Maryam Fawzi [1 ]
Sheat, Attalla M. [1 ]
机构
[1] Univ Mosul, Coll Sci, Dept Chem, Mosul, Iraq
来源
EGYPTIAN JOURNAL OF CHEMISTRY | 2023年 / 66卷 / 06期
关键词
Ullmann reaction; amino acridone derivatives; Schiff bases; terphthaldehyde; N-anthanilic acid; biological activities; COPPER-CATALYZED AMINATION; DOCKING; DESIGN; ACIDS;
D O I
10.21608/EJCHEM.2022.155588.6713
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Ullmann reaction was used to synthesis the N-anthranilic acid by reaction of o-chloro benzoic acid derivatives with o-and p-phenylene diamine, then the compounds were cyclized to amino acridone derivatives using poly(phosphoric acid) (PPA). Terphthaldehyde mono Schiff bases were synthesized by reaction 1:1mole of one of the following ( o-,m-,p-toluidine and p-anisidine) with Terphthaldehyde. Extra Schiff bases were synthesized by reaction of previous prepared amino acridone derivatives with mono Schiff bases of Terphthaldehyde . In addition, other compounds were synthesized by reaction of aforesaid amino acridone derivatives each with 1 mole of Terphthaldehyde, 4-(dimethyl amino)benzaldehyde, 2-formyl benzoic acid and methyl-4-formyl benzoate. All synthesized compounds were characterized by FTIR,1H NMR and 13C NMR spectroscopy. Some of the new synthesized products were examin their antibacterial activities against [Escherichia coli , Klepsiella pneumoniae ,Staphlococcus aurous, Pseudomonas aeroginosa] .
引用
收藏
页码:225 / 234
页数:10
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