Biomarkers of malignant transformation in oral leukoplakia: from bench to bedside

被引：3
作者：
Cai, Xinjia [1 ,3 ]
Zhang, Jianyun [1 ,3 ]
Zhang, Heyu [2 ,3 ]
Li, Tiejun [1 ,3 ]
机构：
[1] Peking Univ, Sch & Hosp Stomatol, Natl Ctr Stomatol, Dept Oral Pathol,Natl Clin Res Ctr Oral Dis,Natl E, Beijing 100081, Peoples R China
[2] Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
[3] Chinese Acad Med Sci 2019RU034, Res Unit Precis Pathol Diag Tumors Oral & Maxillof, Beijing 100081, Peoples R China
来源：
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B | 2023年 / 24卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Oral leukoplakia; Oral squamous cell carcinoma; Malignant transformation; Biomarker; Prognosis; STEM-CELL MARKERS; PROGNOSTIC VALUE; PODOPLANIN EXPRESSION; EPITHELIAL DYSPLASIA; CANCER PROGRESSION; PREDICTIVE MARKER; RISK PREDICTION; DOWN-REGULATION; PROTEIN; LESIONS;
D O I：
10.1631/jzus.B2200589
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oral leukoplakia is a common precursor lesion of oral squamous cell carcinoma, which indicates a high potential of malignancy. The malignant transformation of oral leukoplakia seriously affects patient survival and quality of life; however, it is difficult to identify oral leukoplakia patients who will develop carcinoma because no biomarker exists to predict malignant transformation for effective clinical management. As a major problem in the field of head and neck pathologies, it is imperative to identify biomarkers of malignant transformation in oral leukoplakia. In this review, we discuss the potential biomarkers of malignant transformation reported in the literature and explore the translational probabilities from bench to bedside. Although no single biomarker has yet been applied in the clinical setting, profiling for genomic instability might be a promising adjunct.
引用
收藏
页码：868 / 882
页数：15
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