Characterization of carbapenem-resistant Escherichia coli and Klebsiella: a role for AmpC-producing isolates

被引：1
|
作者：
Rizi, Kobra S. [1 ,2 ]
Aryan, Ehsan [2 ]
Youssefi, Masoud [2 ]
Ghazvini, Kiarash [2 ]
Meshkat, Zahra [2 ]
Amini, Yousef [3 ]
Safdari, Hadi [2 ]
Derakhshan, Mohammad [2 ]
Farsiani, Hadi [2 ]
机构：
[1] Mashhad Univ Med Sci, Sch Med, Dept Microbiol & Virol, Mashhad, Iran
[2] Mashhad Univ Med Sci, Antimicrobial Resistance Res Ctr, Mashhad, Iran
[3] Zahedan Univ Med Sci, Resistant TB Inst, Infect Dis & Trop Med Res Ctr, Zahedan, Iran
来源：
FUTURE MICROBIOLOGY | 2023年
关键词：
AmpC beta-lactamases; antimicrobial resistance; carbapenemase-coding genes; Enterobacterales; extended-spectrum beta-lactamase enzymes; SPECTRUM-BETA-LACTAMASE; HIGH PREVALENCE; ENTEROBACTERIACEAE; PNEUMONIAE; PSEUDOMONAS; MECHANISMS; COMMUNITY; BACTERIA; GENES;
D O I：
10.2217/fmb-2021-0211
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: This study aimed to investigate the role of AmpC enzymes in carbapenem resistance among AmpC/extended-spectrum ss-lactamase (ESBL)-producing clinical isolates of Escherichia coli and Klebsiella spp. Methods: Fifty-six bacterial strains that were AmpC producers were examined. The antibiotic susceptibility test was performed by the disk diffusion and E-test. The prevalence of the plasmid carbapenemase was determined using PCR. Results: The resistance to meropenem in the AmpC(+)/ESBL+ group was 64%, higher than that reported for the AmpC(-)/ESBL+ group. Ten isolates of the carbapenemresistant AmpC producers were negative for carbapenemase-encoding genes. Conclusion: Carbapenem resistance among AmpC-producing isolates with negative results for carbapenemase-encoding genes potentially demonstrates the role of AmpC enzymes among these isolates.
引用
收藏
页码：215 / 223
页数：9
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