Cancer and Trypanosoma cruzi: Tumor induction or protection?

被引：5
作者：
Franco, Pablo Igor Ribeiro [1 ,4 ]
Neto, Jose Rodrigues do Carmo [1 ]
Miguel, Marina Pacheco [1 ,2 ]
Machado, Juliana Reis [3 ]
Celes, Mara Rubia Nunes [1 ]
机构：
[1] Univ Fed Goias, Inst Trop Pathol & Publ Hlth, Dept Biosci & Technol, BR-74605050 Goiania, GO, Brazil
[2] Univ Fed Goias, Vet & Anim Sci Sch, BR-74605050 Goiania, GO, Brazil
[3] Univ Fed Triangulo Mineiro, Inst Biol & Nat Sci, Dept Gen Pathol, BR-38025180 Uberaba, MG, Brazil
[4] Univ Fed Goias, Inst Trop Pathol & Publ Hlth, Postgrad Program Trop Med & Publ Hlth, BR-74605050 Goiania, GO, Brazil
来源：
BIOCHIMIE | 2023年 / 207卷
关键词：
Chagas disease; Neoplasms; Host -parasite interactions; Trypanosoma cruzi; DNA MISMATCH REPAIR; CHAGAS-DISEASE; ENTERIC GLIA; COLON-CANCER; CALRETICULIN; ESOPHAGEAL; CARCINOMA; MEGACOLON; PROMOTES; PATHWAY;
D O I：
10.1016/j.biochi.2022.10.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Trypanosoma cruzi causes Chagas disease, a neglected disease that can be divided, overall, into acute and chronic phases. Understanding the mechanisms underlying its progression is based on the parasite-host interactions occurring during the infection. Although the pathophysiology of the main symptomatic forms of Chagas disease has been the subject of several studies, little is known about their relationship with the development of different types of cancer. Therefore, knowledge regarding the molecular aspects of infection in the host, as well as the influence of the immune response in the parasite and the host, can help to understand the association between Chagas disease and tumor development. This review aims to summarize the main molecular mechanisms related to T. cruzi-dependent carcinogenic development and the mechanisms associated with tumor protection mediated by different parasite components.(c) 2022 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
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收藏
页码：113 / 121
页数：9
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