Regulation of Liver Glucose and Lipid Metabolism by Transcriptional Factors and Coactivators

被引：11
作者：
Ramatchandirin, Balamurugan [1 ]
Pearah, Alexia [1 ]
He, Ling [1 ,2 ]
机构：
[1] Johns Hopkins Univ, Dept Pediat, Sch Med, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Dept Pharmacol & Mol Sci, Sch Med, 600 N Wolfe St, Baltimore, MD 21287 USA
来源：
LIFE-BASEL | 2023年 / 13卷 / 02期
关键词：
fatty liver; obesity; type; 2; diabetes; ELEMENT-BINDING PROTEIN; PROLIFERATOR-ACTIVATED RECEPTORS; ENDOPLASMIC-RETICULUM STRESS; TYPE-2; DIABETES-MELLITUS; FATTY LIVER; INSULIN-RESISTANCE; HEPATIC GLUCONEOGENESIS; PPAR-GAMMA; GENE-EXPRESSION; MESSENGER-RNA;
D O I：
10.3390/life13020515
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The prevalence of nonalcoholic fatty liver disease (NAFLD) worldwide is on the rise and NAFLD is becoming the most common cause of chronic liver disease. In the USA, NAFLD affects over 30% of the population, with similar occurrence rates reported from Europe and Asia. This is due to the global increase in obesity and type 2 diabetes mellitus (T2DM) because patients with obesity and T2DM commonly have NAFLD, and patients with NAFLD are often obese and have T2DM with insulin resistance and dyslipidemia as well as hypertriglyceridemia. Excessive accumulation of triglycerides is a hallmark of NAFLD and NAFLD is now recognized as the liver disease component of metabolic syndrome. Liver glucose and lipid metabolisms are intertwined and carbon flux can be used to generate glucose or lipids; therefore, in this review we discuss the important transcription factors and coactivators that regulate glucose and lipid metabolism.
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页数：23
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共 198 条
[1]   Glucose effectiveness assessed under dynamic and steady state conditions - Comparability of uptake versus production components [J].
Ader, M ;
Ni, TC ;
Bergman, RN .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (06) :1187-1199
[2]   Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice [J].
Aharoni-Simon, Michal ;
Hann-Obercyger, Michal ;
Pen, Svetlana ;
Madar, Zecharia ;
Tirosh, Oren .
LABORATORY INVESTIGATION, 2011, 91 (07) :1018-1028
[3]   Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain [J].
Ahmad, KF ;
Melnick, A ;
Lax, S ;
Bouchard, D ;
Liu, J ;
Kiang, CL ;
Mayer, S ;
Takahashi, S ;
Licht, JD ;
Privé, GG .
MOLECULAR CELL, 2003, 12 (06) :1551-1564
[4]   PPARγ signaling and metabolism: the good, the bad and the future [J].
Ahmadian, Maryam ;
Suh, Jae Myoung ;
Hah, Nasun ;
Liddle, Christopher ;
Atkins, Annette R. ;
Downes, Michael ;
Evans, Ronald M. .
NATURE MEDICINE, 2013, 19 (05) :557-566
[5]   β- and α-Cell Dysfunction in Subjects Developing Impaired Glucose Tolerance Outcome of a 12-Year Prospective Study in Postmenopausal Caucasian Women [J].
Ahren, B. .
DIABETES, 2009, 58 (03) :726-731
[6]   CREB and the CRTC co-activators: sensors for hormonal and metabolic signals [J].
Altarejos, Judith Y. ;
Montminy, Marc .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2011, 12 (03) :141-151
[7]   Foxo1 mediates insulin action on apoC-III and triglyceride metabolism [J].
Altomonte, J ;
Cong, L ;
Harbaran, S ;
Richter, A ;
Xu, J ;
Meseck, M ;
Dong, HJH .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (10) :1493-1503
[8]   Transcriptional activities of nuclear SREBP-1a,-1c, and-2 to different target promoters of lipogenic and cholesterogenic genes [J].
Amemiya-Kudo, M ;
Shimano, H ;
Hasty, AH ;
Yahagi, N ;
Yoshikawa, T ;
Matsuzaka, T ;
Okazaki, H ;
Tamura, Y ;
Iizuka, Y ;
Ohashi, K ;
Osuga, J ;
Harada, K ;
Gotoda, T ;
Sato, R ;
Kimura, S ;
Ishibashi, S ;
Yamada, N .
JOURNAL OF LIPID RESEARCH, 2002, 43 (08) :1220-1235
[9]   E1A-ASSOCIATED P300 AND CREB-ASSOCIATED CBP BELONG TO A CONSERVED FAMILY OF COACTIVATORS [J].
ARANY, Z ;
SELLERS, WR ;
LIVINGSTON, DM ;
ECKNER, R .
CELL, 1994, 77 (06) :799-800
[10]   The MYST family of histone acetyltransferases and their intimate links to cancer [J].
Avvakumov, N. ;
Cote, J. .
ONCOGENE, 2007, 26 (37) :5395-5407
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