Survival and health care costs after inpatient elective surgery: comparison of patients with and without chronic obstructive pulmonary disease

被引：13

作者：

Sankar, Ashwin ^{[1
,2
,3
,4
]}

Thorpe, Kevin ^{[5
,6
]}

McIsaac, Daniel I. ^{[3
,7
,8
,9
]}

Luo, Jin ^{[3
]}

Wijeysundera, Duminda N. ^{[1
,2
,3
,4
]}

Gershon, Andrea S. ^{[3
,5
,10
,11
]}

机构：

[1] St Michaels Hosp, Dept Anesthesia, Unity Hlth Toronto, Toronto, ON, Canada

[2] Univ Toronto, Dept Anesthesiol & Pain Med, Toronto, ON, Canada

[3] ICES Cent, Toronto, ON, Canada

[4] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada

[5] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[6] Appl Hlth Res Ctr AHRC, Toronto, ON, Canada

[7] Univ Ottawa, Dept Anesthesiol & Pain Med, Ottawa, ON, Canada

[8] Ottawa Hosp, Dept Anesthesi ol & Pain Med, Ottawa, ON, Canada

[9] Ottawa Hosp, Res Inst, Ottawa, ON, Canada

[10] Univ Toronto, Dept Med, Div Respirol, Toronto, ON, Canada

[11] Univ Toronto, Sunny brook Hlth Sci Ctr, Dept Med, Div Respirol, Toronto, ON, Canada

来源：

CANADIAN MEDICAL ASSOCIATION JOURNAL | 2023年 / 195卷 / 02期

关键词：

NONCARDIAC SURGERY; ADMINISTRATIVE DATA; RISK; COPD; COMORBIDITIES; OUTCOMES; FRAILTY; COMPLICATIONS; ASSOCIATION; PREVALENCE;

D O I：

10.1503/cmaj.220733

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background:Chronic obstructive pulmonary disease (COPD) is common among surgical patients, and patients with COPD have higher risk for complications and death within 30 days after surgery. We sought to describe the longer-term postoperative survival and costs of patients with COPD compared with those without COPD within 1 year after inpatient elective surgery. Methods:In this retrospective population-based cohort study, we used linked health administrative databases to identify all patients undergoing inpatient elective surgery in Ontario, Canada, from 2005 to 2019. We ascertained COPD status using validated definitions. We followed participants for 1 year after surgery to evaluate survival and costs to the health system. We quantified the association of COPD with survival (Cox proportional hazards models) and costs (linear regression model with log-transformed costs) with partial adjustment (for sociodemographic factors and procedure type) and full adjustment (also adjusting for comorbidities). We assessed for effect modification by frailty, cancer and procedure type. Results:We included 932 616 patients, of whom 170 482 (18%) had COPD. With respect to association with risk of death, COPD had a partially adjusted hazard ratio (HR) of 1.61 (95% confidence interval [CI] 1.58-1.64), and a fully adjusted HR of 1.26 (95% CI 1.24-1.29). With respect to impact on health system costs, COPD was associated with a partially adjusted relative increase of 13.1% (95% CI 12.7%-13.4%), and an increase of 4.6% (95% CI 4.3%-5.0%) with full adjustment. Frailty, cancer and procedure type (such as orthopedic and lower abdominal surgery) modified the association between COPD and outcomes. Interpretation:Patients with COPD have decreased survival and increased costs in the year after surgery. Frailty, cancer and the type of surgical procedure modified associations between COPD and outcomes, and must be considered when risk-stratifying surgical patients with COPD.

引用

页码：E62 / E71

页数：10

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