CRISPR-Cas engineering in food science and sustainable agriculture: recent advancements and applications

被引：8

作者：

Mohammadi, Masoud Aman ^{[1
]}

Maximiano, Mariana Rocha ^{[2
,3
]}

Hosseini, Seyede Marzieh ^{[1
]}

Franco, Octavio Luiz ^{[2
,3
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Student Res Comm, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci Food Sci & Technol,Dept Food Sci & T, Tehran, Iran

[2] Univ Catolica Dom Bosco, Grad Program Biotechnol, S Inova Biotech, Campo Grande, MS, Brazil

[3] Univ Catolica Brasilia, Ctr Anal Prote & Bioquim, Grad Program Genom Sci & Biotechnol, Brasilia, DF, Brazil

来源：

BIOPROCESS AND BIOSYSTEMS ENGINEERING | 2023年 / 46卷 / 04期

关键词：

CRISPR-Cas; Food safety; Bacteria; Antimicrobial; Genome editing; SAFETY CONSIDERATIONS; ESCHERICHIA-COLI; GENOME; CLASSIFICATION; SEQUENCE; TECHNOLOGIES; EVOLUTION; GENE; IDENTIFICATION; ANTIMICROBIALS;

D O I：

10.1007/s00449-022-02842-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The developments in the food supply chain to support the growing population of the world is one of today's most pressing issues, and to achieve this goal improvements should be performed in both crops and microbes. For this purpose, novel approaches such as genome editing (GE) methods have upgraded the biological sciences for genome manipulation and, among such methods, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) are the main exciting innovations since the Green Revolution. CRISPR/Cas systems can be a potent tool for the food industry, improvement of agricultural crops and even for protecting food-grade bacteria from foreign genetic invasive elements. This review introduces the history and mechanism of the CRISPR-Cas system as a genome editing tool and its applications in the vaccination of starter cultures, production of antimicrobials and bioactive compounds, and genome editing of microorganisms.

引用

页码：483 / 497

页数：15