Role of peripheral immune cells in spinal cord injury

被引：16
作者：
Li, Cong [1 ]
Xiong, Wu [1 ]
Wan, Bowen [2 ]
Kong, Guang [3 ]
Wang, Siming [1 ]
Wang, Yingying [4 ]
Fan, Jin [1 ]
机构：
[1] Nanjing Med Univ, Dept Orthoped, Affiliated Hosp 1, Nanjing 210029, Peoples R China
[2] Yangzhou Univ, Subei Peoples Hosp Jiangsu, Dept Orthopaed, Clin Med Coll, Yangzhou, Peoples R China
[3] Nanjing Med Univ, Nanjing 210029, Peoples R China
[4] China Pharmaceut Univ, Dept Pharmaceut Sci, State Key Lab Nat Med, Nanjing 210009, Peoples R China
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2023年 / 80卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Spinal cord injury; Immune system; Inflammation; REGULATORY T-CELLS; MACROPHAGE ACTIVATION; INFLAMMATORY RESPONSE; MYELIN PHAGOCYTOSIS; SECONDARY INJURY; AUTOIMMUNITY; NEUTROPHILS; EFFECTOR; DIFFERENTIATION; EXPRESSION;
D O I：
10.1007/s00018-022-04644-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Secondary spinal cord injury is caused by an inflammatory response cascade, and the process is irreversible. The immune system, as a mediator of inflammation, plays an important role in spinal cord injury. The spinal cord retains its immune privilege in a physiological state. Hence, elucidating the mechanisms by which peripheral immune cells are recruited to the lesion site and function after spinal cord injury is meaningful for the exploration of clinical therapeutic targets. In this review, we provide an overview of the multifaceted roles of peripheral immune cells in spinal cord injury.
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页数：11
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