Sirtuins, a key regulator of ageing and age-related neurodegenerative diseases

被引：16

作者：

Bhatt, Vidhi ^{[1
]}

Tiwari, Anand Krishna ^{[1
]}

机构：

[1] Inst Adv Res, Dept Biol Sci & Biotechnol, Gandhinagar 382426, Gujarat, India

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2023年 / 133卷 / 10期

关键词：

Sirtuins; ageing; human; neurodegenerative diseases; LIFE-SPAN EXTENSION; HISTONE DEACETYLASE INHIBITORS; SMALL-MOLECULE ACTIVATORS; MITOCHONDRIAL DYSFUNCTION; HUNTINGTONS-DISEASE; CALORIE RESTRICTION; ALZHEIMERS-DISEASE; SIRT1; ACTIVATION; OXIDATIVE STRESS; PYRUVATE-DEHYDROGENASE;

D O I：

10.1080/00207454.2022.2057849

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sirtuins are Nicotinamide Adenine Dinucleotide (NAD(+)) dependent class CYRILLIC CAPITAL LETTER BYELORUSSIAN-UKRAINIAN I Iota Iota histone deacetylases enzymes (HDACs) present from lower to higher organisms such as bacteria (Sulfolobus solfataricus L. major), yeasts (Saccharomyces cerevisiae), nematodes (Caenorhabditis elegans), fruit flies (Drosophila melanogaster), humans (Homo sapiens sapiens), even in plants such as rice (Oryza sativa), thale cress (Arabidopsis thaliana), vine (Vitis vinifera L.) tomato (Solanum lycopersicum). Sirtuins play an important role in the regulation of various vital cellular functions during metabolism and ageing. It also plays a neuroprotective role by modulating several biological pathways such as apoptosis, DNA repair, protein aggregation, and inflammatory processes associated with ageing and neurodegenerative diseases. In this review, we have presented an updated Sirtuins and its role in ageing and age-related neurodegenerative diseases (NDDs). Further, this review also describes the therapeutic potential of Sirtuins and the use of Sirtuins inhibitor/activator for altering the NDDs disease pathology.

引用

页码：1167 / 1192

页数：26

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