Dominant immune cells in pregnancy and pregnancy complications: T helper cells (TH1/TH2, TH17/Treg cells), NK cells, MDSCs, and the immune checkpoints

被引：26

作者：

Esparvarinha, Mojgan ^{[1
,2
]}

Madadi, Sahar ^{[3
]}

Aslanian-Kalkhoran, Lida ^{[1
,2
]}

Nickho, Hamid ^{[4
,5
]}

Dolati, Sanam ^{[6
]}

Pia, Helen ^{[7
]}

Danaii, Shahla ^{[8
]}

Taghavi, Simin ^{[3
]}

Yousefi, Mehdi ^{[1
,7
]}

机构：

[1] Tabriz Univ Med Sci, Fac Med, Dept Immunol, Tabriz, Iran

[2] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Womens Reprod Hlth Res Ctr, Tabriz, Iran

[4] Iran Univ Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[5] Iran Univ Med Sci, Immunol Res Ctr, Inst Immunol & Infect Dis, Tehran, Iran

[6] Tabriz Univ Med Sci, Phys Med & Rehabil Res Ctr, Aging Res Inst, Tabriz, Iran

[7] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[8] Eastern Azerbaijan ACECR ART Ctr, Gynecol Dept, Eastern Azerbaijan Branch ACECR, Tabriz, Iran

来源：

CELL BIOLOGY INTERNATIONAL | 2023年 / 47卷 / 03期

关键词：

immune checkpoint; immune tolerance; pregnancy; pregnancy complication; MATERNAL-FETAL INTERFACE; SUPPRESSOR-CELLS; PERIPHERAL-BLOOD; FETOMATERNAL TOLERANCE; IMPLANTATION FAILURES; INHIBITORY RECEPTORS; CUTTING EDGE; PD-1; PATHWAY; TREG CELLS; ACTIVATION;

D O I：

10.1002/cbin.11955

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pregnancy problems including recurrent pregnancy loss, repeated implantation failure and pre-eclampsia are common problems in the reproductive ages. Different reasons such as genetic, immunological, and environmental agents and also infections could develop these complications. In those cases in which the cause of the abortion is diagnosed, the chance of a successful pregnancy is increased by eliminating defective factors. However, in patients with unknown causes, there may be an imbalance in immune cells pattern. As a matter of fact, an inappropriate immune response is often associated with a failed pregnancy. Hence, the focus of treatment is to increase tolerance, not to suppress maternal immune system. These findings are linked to an elevated number of Treg cells and immune checkpoints through normal pregnancy. The present review discusses the balance of myeloid-derived suppressor cells, natural killer cells, T cells, and immune checkpoints, and also targeting them to maintain pregnancy and prevent associated complications.

引用

页码：507 / 519

页数：13

共 146 条

[1] NK cell frequency and cytotoxicity in correlation to pregnancy outcome and response to IVIG therapy among women with recurrent pregnancy loss [J].