Microstates imbalance is associated with a functional dysregulation of the resting-state networks in obsessive-compulsive disorder: a high-density electrical neuroimaging study using the TESS method

被引:11
作者
Thirioux, Berangere [1 ,2 ]
Langbour, Nicolas [1 ,2 ]
Bokam, Prasanth [1 ]
Renaudin, Lea [1 ]
Wassouf, Issa [1 ,2 ]
Harika-Germaneau, Ghina [1 ,2 ,3 ]
Jaafari, Nematollah [1 ,2 ,3 ]
机构
[1] Ctr Hosp Henri Laborit, Unite Rech Clin Pierre Deniker, F-86021 Poitiers, France
[2] Univ Poitiers, Ctr Rech Sur Cognit & Apprentissage, CNRS 7295, F-86021 Poitiers, France
[3] Univ Poitiers, Fac Med & Pharm, F-86021 Poitiers, France
关键词
EEG microstates; high-density EEG; obsessive-compulsive disorder; resting-state networks; TESS method; ANTERIOR CINGULATE CORTEX; DEFAULT-MODE; PHYSIOLOGICAL CONDITION; INDEPENDENT COMPONENT; UNMEDICATED ADULTS; SALIENCE NETWORKS; BRAIN NETWORKS; MOTOR CONTROL; EEG; CONNECTIVITY;
D O I
10.1093/cercor/bhac229
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The dysfunctional patterns of microstates dynamics in obsessive-compulsive disorder (OCD) remain uncertain. Using high-density electrical neuroimaging (EEG) at rest, we explored microstates deterioration in OCD and whether abnormal microstates patterns are associated with a dysregulation of the resting-state networks interplay. We used EEG microstates analyses, TESS method for sources reconstruction, and General Linear Models to test for the effect of disease severity on neural responses. OCD patients exhibited an increased contribution and decreased duration of microstates C and D, respectively. Activity was decreased in the Salience Network (SN), associated with microstate C, but increased in the Default Mode Network (DMN) and Executive Control Network (ECN), respectively, associated with microstates E and D. The hyperactivity of the right angular gyrus in the ECN correlated with the symptoms severity. The imbalance between microstates C and D invalidates the hypothesis that this electrophysiological pattern is specific to psychosis. Demonstrating that the SN-ECN dysregulation manifests as abnormalities in microstates C and D, we confirm that the SN deterioration in OCD is accompanied by a failure of the DMN to deactivate and aberrant compensatory activation mechanisms in the ECN. These abnormalities explain typical OCD clinical features but also detachment from reality, shared with psychosis.
引用
收藏
页码:2593 / 2611
页数:19
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