Pulmonary Hypertension Secondary to Myxomatous Mitral Valve Disease in Dogs: Current Insights into the Histological Manifestation and Its Determining Factors

被引:2
作者
Grzeczka, Arkadiusz [1 ]
Paslawska, Urszula [2 ]
Graczyk, Szymon [1 ]
Antosik, Paulina [3 ]
Zawadzki, Marcin [1 ]
Paslawski, Robert [4 ]
机构
[1] Nicolaus Copernicus Univ, Inst Vet Med, Fac Biol & Vet Sci, Dept Basic & Preclin Sci, PL-87100 Torun, Poland
[2] Nicolaus Copernicus Univ, Inst Vet Med, Fac Biol & Vet Sci, Dept Diagnost & Clin Sci, PL-87100 Torun, Poland
[3] Nicolaus Copernicus Univ, Coll Med Bydgoszcz, Dept Clin Pathomorphol, PL-85094 Bydgoszcz, Poland
[4] Nicolaus Copernicus Univ, Inst Vet Med, Fac Biol & Vet Sci, Dept Vet Surg, PL-87100 Torun, Poland
来源
APPLIED SCIENCES-BASEL | 2024年 / 14卷 / 06期
关键词
endothelin; nitric oxide; serotonin; myxomatous mitral valve disease; pulmonary vessels; pulmonary; ENDOTHELIAL GROWTH-FACTOR; CELL DISTRIBUTION WIDTH; KING CHARLES SPANIELS; PROTEIN-KINASE-C; NITRIC-OXIDE; HEART-FAILURE; SEROTONIN TRANSPORTER; ARTERIAL-HYPERTENSION; VASCULAR REACTIVITY; SIGNAL-TRANSDUCTION;
D O I
10.3390/app14062577
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Pulmonary venous hypertension (PVH) is caused by deteriorating left ventricular function. The most common cause of PVH in dogs is myxomatous mitral valve degeneration (MMVD). It causes left ventricular volume overload and an increase in left atrial and pulmonary venous pressure (PVH), which leads to pulmonary vascular wall remodeling and contributes to the perpetuation and worsening of PVH. Pulmonary vascular wall remodeling is also characteristic of pulmonary arterial hypertension (PAH). However, the changes in PVH arise secondary to heart failure and vascular remodeling progresses as the disease progresses. On the other hand, PAH is a primary disease that can be triggered, for example, by the use of certain drugs. Similar structural changes may suggest the influence of similar pathophysiological mechanisms or the intermediation of similar mediators. Therefore, this article discusses recent and hitherto uncommented findings elucidating the pathophysiology of the processes and influences on the pattern of histological changes observed in pulmonary hypertension secondary to degenerative mitral valve disease. In particular, we focus on the activity of factors such as endothelin, serotonin, and nitric oxide, which are involved in pulmonary vascular wall remodeling in both PVH and PAH.
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页数:15
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共 138 条
  • [131] Pulmonary Hypertension Due to Left Heart Diseases
    Vachiery, Jean-Luc
    Adir, Yochai
    Albert Barbera, Joan
    Champion, Hunter
    Coghlan, John Gerard
    Cottin, Vincent
    De Marco, Teresa
    Galie, Nazzareno
    Ghio, Stefano
    Gibbs, J. Simon R.
    Martinez, Fernando
    Semigran, Marc
    Simonneau, Gerald
    Wells, Athol
    Seeger, Werner
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (25) : D100 - D108
  • [132] Transition from post-capillary pulmonary hypertension to combined pre- and post-capillary pulmonary hypertension in swine: a key role for endothelin
    van Duin, Richard W. B.
    Stam, Kelly
    Cai, Zongye
    Uitterdijk, Andre
    Garcia-Alvarez, Ana
    Ibanez, Borja
    Danser, A. H. Jan
    Reiss, Irwin K. M.
    Duncker, Dirk J.
    Merkus, Daphne
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 2019, 597 (04): : 1157 - 1173
  • [133] WANG HY, 1990, MOL PHARMACOL, V37, P75
  • [134] Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH
    White, Kevin
    Loughlin, Lynn
    Maqbool, Zakia
    Nilsen, Margaret
    McClure, John
    Dempsie, Yvonne
    Baker, Andrew H.
    MacLean, Margaret R.
    [J]. PHYSIOLOGICAL GENOMICS, 2011, 43 (08) : 417 - 437
  • [135] TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension
    Xia, Yang
    Fu, Zhenzhen
    Hu, Jinxing
    Huang, Chun
    Paudel, Omkar
    Cai, Shaoxi
    Liedtke, Wolfgang
    Sham, James S. K.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2013, 305 (07): : C704 - C715
  • [136] Clinical update on pulmonary hypertension
    Yaghi, Salim
    Novikov, Anastasia
    Trandafirescu, Theo
    [J]. JOURNAL OF INVESTIGATIVE MEDICINE, 2020, 68 (04) : 821 - 827
  • [137] Prevalence of Pulmonary Hypertension in Dogs with Degenerative Mitral Valve Disease
    Yamini, S. Hamsa
    Jeyaraja, K.
    Chandrasekhar, M.
    Kavitha, S.
    [J]. INDIAN JOURNAL OF ANIMAL RESEARCH, 2020, 54 (09) : 1136 - 1142
  • [138] Pulmonary arteriopathy and idiopathic pulmonary arterial hypertension in six dogs
    Zabka, T. S.
    Campbell, F. E.
    Wilson, D. W.
    [J]. VETERINARY PATHOLOGY, 2006, 43 (04) : 510 - 522