Pulmonary Hypertension Secondary to Myxomatous Mitral Valve Disease in Dogs: Current Insights into the Histological Manifestation and Its Determining Factors

被引:2
作者
Grzeczka, Arkadiusz [1 ]
Paslawska, Urszula [2 ]
Graczyk, Szymon [1 ]
Antosik, Paulina [3 ]
Zawadzki, Marcin [1 ]
Paslawski, Robert [4 ]
机构
[1] Nicolaus Copernicus Univ, Inst Vet Med, Fac Biol & Vet Sci, Dept Basic & Preclin Sci, PL-87100 Torun, Poland
[2] Nicolaus Copernicus Univ, Inst Vet Med, Fac Biol & Vet Sci, Dept Diagnost & Clin Sci, PL-87100 Torun, Poland
[3] Nicolaus Copernicus Univ, Coll Med Bydgoszcz, Dept Clin Pathomorphol, PL-85094 Bydgoszcz, Poland
[4] Nicolaus Copernicus Univ, Inst Vet Med, Fac Biol & Vet Sci, Dept Vet Surg, PL-87100 Torun, Poland
来源
APPLIED SCIENCES-BASEL | 2024年 / 14卷 / 06期
关键词
endothelin; nitric oxide; serotonin; myxomatous mitral valve disease; pulmonary vessels; pulmonary; ENDOTHELIAL GROWTH-FACTOR; CELL DISTRIBUTION WIDTH; KING CHARLES SPANIELS; PROTEIN-KINASE-C; NITRIC-OXIDE; HEART-FAILURE; SEROTONIN TRANSPORTER; ARTERIAL-HYPERTENSION; VASCULAR REACTIVITY; SIGNAL-TRANSDUCTION;
D O I
10.3390/app14062577
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Pulmonary venous hypertension (PVH) is caused by deteriorating left ventricular function. The most common cause of PVH in dogs is myxomatous mitral valve degeneration (MMVD). It causes left ventricular volume overload and an increase in left atrial and pulmonary venous pressure (PVH), which leads to pulmonary vascular wall remodeling and contributes to the perpetuation and worsening of PVH. Pulmonary vascular wall remodeling is also characteristic of pulmonary arterial hypertension (PAH). However, the changes in PVH arise secondary to heart failure and vascular remodeling progresses as the disease progresses. On the other hand, PAH is a primary disease that can be triggered, for example, by the use of certain drugs. Similar structural changes may suggest the influence of similar pathophysiological mechanisms or the intermediation of similar mediators. Therefore, this article discusses recent and hitherto uncommented findings elucidating the pathophysiology of the processes and influences on the pattern of histological changes observed in pulmonary hypertension secondary to degenerative mitral valve disease. In particular, we focus on the activity of factors such as endothelin, serotonin, and nitric oxide, which are involved in pulmonary vascular wall remodeling in both PVH and PAH.
引用
收藏
页数:15
相关论文
共 138 条
  • [91] Important Functions and Molecular Mechanisms of Mitochondrial Redox Signaling in Pulmonary Hypertension
    Reyes-Garcia, Jorge
    Carbajal-Garcia, Abril
    Di Mise, Annarita
    Zheng, Yun-Min
    Wang, Xiangdong
    Wang, Yong-Xiao
    [J]. ANTIOXIDANTS, 2022, 11 (03)
  • [92] The crucial role of vascular permeability factor/vascular endothelial growth factor in angiogenesis: a historical review
    Ribatti, D
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2005, 128 (03) : 303 - 309
  • [93] Rich S., 2001, Cardiology for the Primary Care Physician, P313
  • [94] Peptide barcodes in dogs affected by mitral valve disease with and without pulmonary hypertension using MALDI-TOF MS and LC-MS/MS
    Riengvirodkij, Nattapon
    Roytrakul, Sittiruk
    Jaresitthikunchai, Janthima
    Phaonakrop, Narumon
    Charoenlappanich, Sawanya
    Sakcamduang, Walasinee
    [J]. PLOS ONE, 2021, 16 (08):
  • [95] Roumier A, 2019, SEROTONIN: THE MEDIATOR THAT SPANS EVOLUTION, P181, DOI 10.1016/B978-0-12-800050-2.00010-3
  • [96] Current concepts - Primary pulmonary hypertension
    Rubin, LJ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (02) : 111 - 117
  • [97] Short-Term Effects of Sacubitril/valsartan on Echocardiographic Parameters in Dogs With Symptomatic Myxomatous Mitral Valve Disease
    Saengklub, Nakkawee
    Pirintr, Prapawadee
    Nampimoon, Thanida
    Kijtawornrat, Anusak
    Chaiyabutr, Narongsak
    [J]. FRONTIERS IN VETERINARY SCIENCE, 2021, 8
  • [98] Histopathological changes of pulmonary vascular remodeling in dogs affected with pulmonary hypertension secondary to degenerative mitral valve disease
    Sakarin, S.
    Rungsipipat, A.
    Surachetpong, S. D.
    [J]. JOURNAL OF VETERINARY CARDIOLOGY, 2021, 36 : 141 - 152
  • [99] Proteomic analysis of pulmonary arteries and lung tissues from dogs affected with pulmonary hypertension secondary to degenerative mitral valve disease
    Sakarin, Siriwan
    Rungsipipat, Anudep
    Roytrakul, Sittiruk
    Jaresitthikunchai, Janthima
    Phaonakrop, Narumon
    Charoenlappanit, Sawanya
    Thaisakun, Siriwan
    Surachetpong, Sirilak Disatian
    [J]. PLOS ONE, 2024, 19 (01):
  • [100] Perivascular inflammatory cells and their association with pulmonary arterial remodelling in dogs with pulmonary hypertension due to myxomatous mitral valve disease
    Sakarin, Siriwan
    Rungsipipat, Anudep
    Surachetpong, Sirilak Disatian
    [J]. VETERINARY RESEARCH COMMUNICATIONS, 2023, 47 (03) : 1505 - 1521