Patients With Chronic Spontaneous Urticaria Who Have Wheals, Angioedema, or Both, Differ Demographically, Clinically, and in Response to Treatment-Results From CURE

被引：12

作者：

Buttgereit, Thomas ^{[1
,2
,3
,4
]}

Vera, Carolina ^{[1
,2
,3
,4
]}

Aulenbacher, Felix ^{[1
,2
,3
,4
]}

Church, Martin K. ^{[1
,2
,3
,4
]}

Hawro, Tomasz ^{[5
]}

Asero, Riccardo ^{[6
]}

Bauer, Andrea ^{[7
]}

Bizjak, Mojca ^{[8
]}

Bouillet, Laurence ^{[9
]}

Dissemond, Joachim ^{[10
]}

Fomina, Daria ^{[11
,12
]}

Gimenez-Arnau, Ana M. ^{[13
]}

Grattan, Clive ^{[14
]}

Gregoriou, Stamatios ^{[15
]}

Kulthanan, Kanokvalai ^{[16
]}

KasPerska-Zajac, Alicja ^{[17
]}

Kocatuerk, Emek ^{[1
,2
,3
,4
,18
]}

Makris, Michael ^{[19
]}

Kolkhir, Pavel ^{[1
,2
,3
,4
]}

Weller, Karsten ^{[1
,2
,3
,4
]}

Magerl, Markus ^{[1
,2
,3
,4
]}

Maurer, Marcus ^{[1
,2
,3
,4
,20
]}

机构：

[1] Charite Univ Med Berlin, Inst Allergol, Berlin, Germany

[2] Free Univ Berlin, Berlin, Germany

[3] Humboldt Univ, Berlin, Germany

[4] Fraunhofer Inst Translat Med & Pharmacol ITMP, Inst Allergol, Allergol & Immunol, Berlin, Germany

[5] Univ Med Ctr Schleswig Holstein, Inst & Comprehens Ctr Inflammat Med, Dept Dermatol Allergol & Venerol, Lubeck, Germany

[6] Clin San Carlo, Dept Allergol, Milan, Italy

[7] Tech Univ Dresden, Dept Dermatol, Univ Hosp Carl Gustav Carus, Dresden, Germany

[8] Univ Clin Resp & Allerg Dis Golnik, Div Allergy, Golnik, Slovenia

[9] CHU Grenobles, Alpes, CREAK Ctr Natl Reference Angioedemes, Internal Med, Grenoble, France

[10] Univ Essen Gesamthsch, Dept Dermatol Venerol & Allergol, Essen, Germany

[11] Moscow Minist Healthcare, Clin State Hosp 52, Ctr Allergy & Immunol, Moscow, Russia

[12] Sechenov Univ, IM Sechenov First Moscow State Med Univ, Dept Clin Immunol & Allergol, Moscow, Russia

[13] Univ Pompeu Fabra, Inst Mar Invest Med, Dept Dermatol, Barcelona, Spain

[14] Guys Hosp, St Johns Inst Dermatol, London, England

[15] Natl & Kapodistrian Univ Athens, Andreas Sygros Hosp, Dept Dermatol Venereol 1, Athens, Greece

[16] Mahidol Univ, Fac Med, Dept Dermatol, Siriraj Hosp, Bangkok, Thailand

[17] Med Univ Silesia, European Ctr Diag & Treatment Urticar Angioedema, GA2LEN UCARE Network, Katowice, Poland

[18] Koc Univ, Sch Med, Dept Dermatol, Istanbul, Turkiye

[19] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Dept Dermatol & Venereol 2, Allergy Unit D Kalogeromitros, Athens, Greece

[20] Charite Univ Med Berlin, Inst Allergol, Campus Benjamin Franklin, D-12203 Berlin, Germany

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2023年 / 11卷 / 11期

关键词：

CURE registry; Chronic spontaneous urticaria; CSU; Angioedema; Recurrent; Without wheals; REPORTED OUTCOME INSTRUMENT; QUALITY-OF-LIFE; VALIDATION;

D O I：

10.1016/j.jaip.2023.08.020

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

BACKGROUND: Patients with chronic spontaneous urticaria (CSU) have spontaneous wheals (W), angioedema (AE), or both, for longer than 6 weeks. Clinical differences between patients with standalone W, standalone AE, and W and AE (W+AE) remain incompletely understood. OBJECTIVE: To compare W, AE, and W+AE CSU patients regarding demographics, disease characteristics, comorbidities, disease burden, and treatment response.METHODS: Baseline data from 3,698 CSU patients in the ongoing, prospective, international, multicenter, observational Chronic Urticaria REgistry (CURE) were analyzed (data cut: September 2022).RESULTS: Across all CSU patients, 59%, 36%, and 5% had W+AE, W, and AE, respectively. The W+AE patients, compared with W and AE patients, showed the lowest male-to female ratio (0.33), higher rates of concomitant psychiatric disease (17% vs 11% vs 6%, respectively), autoimmune disease (13% vs 7% vs 9%, respectively), and nonsteroidal antiinflammatory drug (NSAID) hypersensitivity (9% vs 5% vs 2%, respectively) and the highest disease impact. The W patients, compared with W+AE and AE patients, showed the lowest rates of concomitant hypertension (15% vs 21% vs 40%, respectively) and obesity (11% vs 16% vs 17%, respectively), the highest rate of concomitant inducible urticaria (24% vs 22% vs 6%, respectively), and shorter W duration. The AE patients, compared with W+AE and W patients, were older at disease onset, showed longer AE duration, and the best response to increased doses of H1-antihistamines (58% vs 24% vs 31%, respectively) and omalizumab (92% vs 67% vs 60%, respectively).CONCLUSIONS: Our findings provide a better understanding of CSU phenotypes and may guide patient care and research efforts that aim to link them to pathogenic drivers.(c) 2023 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology

引用

页码：3515 / +

页数：15

共 34 条

[1] A new tool to evaluate the impact of chronic urticaria on quality of life:: chronic urticaria quality of life questionnaire (CU-Q2oL) [J].