The Degradation and Aging of Biological Systems as a Process of Information Loss and Entropy Increase

被引：1

作者：

Aristov, Vladimir V. ^{[1
]}

Karnaukhov, Alexey V. ^{[2
]}

Buchelnikov, Anatoly S. ^{[3
,4
]}

Levchenko, Vladimir F. ^{[5
]}

Nechipurenko, Yury D. ^{[4
]}

机构：

[1] Russian Acad Sci, Fed Res Ctr Comp Sci & Control, Vavilova Str 40, Moscow 119333, Russia

[2] Russian Acad Sci, Inst Cell Biophys, Inst skaya Str 3, Pushchino 142290, Moskovskaya obl, Russia

[3] Sevastopol State Univ, Lab Mol & Cellular Biophys, Univ Skaya Str 33, Sevastopol 299053, Russia

[4] Russian Acad Sci, Engelhardt Inst Mol Biol, Lab DNA Prot Interact, Vavilova Str 32, Moscow 119991, Russia

[5] Russian Acad Sci, Sechenov Inst Evolutionary Physiol & Biochem, Thorez 44, St Petersburg 194223, Russia

来源：

ENTROPY | 2023年 / 25卷 / 07期

关键词：

aging of biological systems; statistical entropy; Schrodinger's concepts; negentropy feeding; Kullback-Leibler entropy; skin age;

D O I：

10.3390/e25071067

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The problem of the degradation and aging of bioorganisms is herein considered from the viewpoint of statistical physics. Two typical timescales in biological systems-the time of metabolic processes and the time of the life cycle-are used. A kinetic equation describing the small timescales of the systems' characteristic processes in is proposed. Maintaining a biosystem in a time-stable state requires a constant inflow of negative entropy (negentropy). Ratios are proposed to evaluate the aging and degradation of systems in terms of entropy. As an example, the aging of the epithelium is studied. The connection of our approach to the information theory of aging is discussed, as well as theoretical constructions related to the concept of cooperon and its changing with time.

引用

页数：13

共 44 条

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