Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis

被引：1

作者：

Akiyama, Yusuke ^{[1
]}

Katsuki, Shunsuke ^{[2
]}

Matoba, Tetsuya ^{[2
]}

Nakano, Yasuhiro ^{[2
]}

Takase, Susumu ^{[2
]}

Nakashiro, Soichi ^{[3
]}

Yamamoto, Mitsutaka ^{[4
]}

Mukai, Yasushi ^{[5
]}

Inoue, Shujiro ^{[6
]}

Oi, Keiji ^{[4
]}

Higo, Taiki ^{[7
]}

Takemoto, Masao ^{[8
]}

Suematsu, Nobuhiro ^{[4
]}

Eshima, Kenichi ^{[9
]}

Miyata, Kenji ^{[10
]}

Usui, Makoto ^{[11
]}

Sadamatsu, Kenji ^{[12
]}

Kadokami, Toshiaki ^{[13
]}

Hironaga, Kiyoshi ^{[14
]}

Ichi, Ikuyo ^{[15
]}

Todaka, Koji ^{[16
]}

Kishimoto, Junji ^{[16
]}

Tsutsui, Hiroyuki ^{[17
,18
]}

机构：

[1] Kyushu Univ, Dept Cardiovasc Resp & Geriatr Med, Beppu Hosp, Oita 8740838, Japan

[2] Kyushu Univ Hosp, Dept Cardiovasc Med, Fukuoka 8128582, Japan

[3] Saiseikai Fukuoka Gen Hosp, Dept Cardiovasc Med, Fukuoka 8100001, Japan

[4] Harasanshin Hosp, Dept Cardiovasc Med, Fukuoka 8120033, Japan

[5] Japanese Red Cross Fukuoka Hosp, Dept Cardiovasc Med, Fukuoka 8150082, Japan

[6] Natl Hosp Org Kyushu Med Ctr, Dept Cardiovasc Med, Fukuoka 8100065, Japan

[7] Wakaba Heart Clin, Fukuoka 8100073, Japan

[8] Steel Mem Yahata Hosp, Cardiovasc Ctr, Fukuoka 8058508, Japan

[9] Matsuguchi Internal Med & Cardiol Clin, Fukuoka 8140133, Japan

[10] Kyushu Hosp, Japan Community Hlth Care Org, Dept Cardiovasc Med, Fukuoka 8068501, Japan

[11] Hamanomachi Hosp, Dept Cardiovasc Med, Fukuoka 8100072, Japan

[12] Omuta City Hosp, Dept Cardiovasc Med, Fukuoka 8360861, Japan

[13] Saiseikai Futsukaichi Hosp, Dept Cardiovasc Med, Fukuoka 8188516, Japan

[14] Fukuoka City Hosp, Dept Cardiovasc Med, Fukuoka 8120046, Japan

[15] Ochanomizu Univ, Grad Sch Humanities & Sci, Tokyo 1128610, Japan

[16] Kyushu Univ Hosp, Ctr Clin & Translat Res, Fukuoka 8128582, Japan

[17] Int Univ Hlth & Welf, Sch Med, Fukuoka 8318501, Japan

[18] Int Univ Hlth & Welf, Grad Sch, Fukuoka 8318501, Japan

来源：

NUTRIENTS | 2023年 / 15卷 / 13期

基金：

日本学术振兴会;

关键词：

oxysterol; cardiovascular disease; cholesterol metabolism; ABSORPTION; STEROL; 24S-HYDROXYCHOLESTEROL; SIMVASTATIN; EZETIMIBE; MORTALITY; OXIDATION; STATINS;

D O I：

10.3390/nu15132997

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Oxysterols have been implicated in the pathogenesis of cardiovascular diseases. Serum levels of oxysterols could be positively correlated with cholesterol absorption and synthesis. However, physiological regulation of various serum oxysterols is largely unknown. The aim of this study was to investigate the relationship between clinical factors and cholesterol metabolism markers, and identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease. Subjects (n = 207) who underwent coronary stenting between 2011 and 2013 were studied cross-sectionally. We measured lipid profiles including serum oxysterols. As for the serum biomarkers of cholesterol synthesis and absorption, oxysterol levels were positively correlated with campesterol and lathosterol. Covariance structure analysis revealed that dyslipidemia and statin usage had a positive correlation with "cholesterol absorption". Statin usage also had a positive correlation with "cholesterol synthesis". Several oxysterols associated with cholesterol absorption and/or synthesis. In conclusion, we elucidated the potential clinical factors that may affect cholesterol metabolism, and the associations between various oxysterols with cholesterol absorption and/or synthesis in patients with coronary artery disease.

引用

页数：14

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