Early-life exposure to di (2-ethyl-hexyl) phthalate: Role in children with endocrine disorders

被引：4

作者：

Zeng, Fa ^{[1
]}

Zhang, Luodan ^{[2
]}

Deng, Fang ^{[2
]}

Lou, Shuiping ^{[1
]}

机构：

[1] Shenzhen Longhua Matern & Child Healthcare Hosp, Shenzhen, Peoples R China

[2] Anhui Med Univ, Anhui Prov Childrens Hosp, Dept Nephrol, Childrens Hosp, Hefei, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷

关键词：

di (2-ethyl-hexyl) phthalate (DEHP); endocrine-disrupting chemicals (EDCs); early-life; placenta; offspring; lipid and glucose; PRENATAL EXPOSURE; DEVELOPMENTAL ORIGINS; BISPHENOL-A; BODY-SIZE; CHILDHOOD; OBESITY; MECHANISMS; DISEASE; HEALTH;

D O I：

10.3389/fcell.2023.1115229

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Di (2-ethyl-hexyl) phthalate (DEHP), one of endocrine-disrupting chemicals (EDCs), has widespread concern due to its serious health hazards. Exposure to DEHP in the early stage of life affects fetal metabolic and endocrine function, which even would cause genetic lesions. To date, it is widely believed that the increasing incidence of childhood obesity and diabetes in adolescents is related to the impact of DEHP on glucose and lipid homeostasis in children. However, there remains a knowledge gap to recognize these adverse effects. Thus, in this review, besides the exposure routes and levels of DEHP, we further outline the effects of early-life exposure to DEHP on children and potential mechanisms, focusing on the aspect of metabolic and endocrine homeostasis.

引用

页数：5

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