PNPLA3 I148M and response to treatment for hepatic steatosis: A systematic review

被引:13
作者
Boeckmans, Joost [1 ]
Gatzios, Alexandra [1 ]
Schattenberg, Joern M. [2 ]
Koek, Ger H. [3 ,4 ]
Rodrigues, Robim M. [1 ]
Vanhaecke, Tamara [1 ]
机构
[1] Vrije Univ Brussel, Fac Med & Pharm, Dept Vitro Toxicol & Dermato Cosmetol, Brussels, Belgium
[2] Univ Med Ctr Mainz, Metab Liver Res Ctr, Dept Med, Mainz, Germany
[3] Maastricht Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Med Ctr, Maastricht, Netherlands
[4] Maastricht Univ, Sch Nutr & Translat Res Metab, Maastricht, Netherlands
关键词
genetics; hepatic steatosis; non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); patatin-like phospholipase domain-containing protein 3 (PNPLA3); FATTY LIVER-DISEASE; LIFE-STYLE MODIFICATION; GENETIC PREDISPOSITION; DOCOSAHEXAENOIC ACID; NAFLD; POLYMORPHISM; ADIPONUTRIN; REDUCTION; CHILDREN; P.I148M;
D O I
10.1111/liv.15533
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
BackgroundIt is unclear whether the patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 C-to-G single nucleotide polymorphism, resulting in the substitution of isoleucine to methionine at position 148 (I148M), impedes regression of hepatic steatosis when treating non-alcoholic fatty liver disease (NAFLD). ObjectivesInvestigate if carriage of the PNPLA3 148M allele affects the anti-steatotic efficacy of all possible anti-NAFLD interventions, identify gaps in current knowledge and provide guidance for individual treatment. MethodsResearch available in public databases was searched up to 13 November 2022. Studies were included if a treatment in NAFLD patients decreased hepatic steatosis in the pooled patient group or a PNPLA3 I148M polymorphism subgroup (II/IM/MM). The risk of bias was assessed using the Cochrane Risk-Of-Bias 2 Tool and the Newcastle-Ottawa Scale. ResultsModerate evidence indicates that NAFLD patients homozygous for the PNPLA3 148M allele benefit less or not at all from omega-3 carboxylic acids to decrease liver fat, while the PNPLA3 148I allele shows moderate benefit. Low evidence suggests that interventions employing lifestyle changes are more effective to reduce liver fat in NAFLD patients homozygous for the PNPLA3 148M allele compared to patients with wild-type PNPLA3. ConclusionsNAFLD patients homozygous for the PNPLA3 148M allele might not benefit from omega-3 carboxylic acids to reduce hepatic steatosis in contrast to patients with wild-type PNPLA3. Instead, patients with two PNPLA3 148M alleles should be especially advised to adopt lifestyle changes. Genotyping for PNPLA3 I148M should be encouraged in therapeutic studies for NAFLD. Registration Number (Prospero)CRD42022375028.
引用
收藏
页码:975 / 988
页数:14
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