Role of chemokine receptor 2 in rheumatoid arthritis: A research update

被引：8

作者：

Chen, Weile ^{[1
]}

Zhu, Xiangling ^{[1
]}

Xu, Zhen ^{[1
]}

Jiang, Haifeng ^{[1
]}

Wu, Xuming ^{[1
]}

Hong, Wenming ^{[2
]}

Wang, Xinming ^{[2
]}

Tu, Jiajie ^{[1
,3
]}

Wei, Wei ^{[1
,3
]}

机构：

[1] Anhui Med Univ, Inst Clin Pharmacol, Anhui Collaborat Innovat Ctr Antiinflammatory & Im, Key Lab Antiinflammatory & Immune Med,Minist Educ, Hefei, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China

[3] 81 Meishan Rd, Hefei, Anhui, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2023年 / 116卷

基金：

中国国家自然科学基金;

关键词：

CCR2; CCL2; Rheumatoid arthritis; Rheumatoid arthritis -related cells; Therapeutic target; FIBROBLAST-LIKE SYNOVIOCYTES; COLLAGEN-INDUCED ARTHRITIS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; PRO-INFLAMMATORY CYTOKINES; ADJUVANT-INDUCED ARTHRITIS; OXIDATIVE STRESS; DISEASE-ACTIVITY; CCR2; EXPRESSION; CELLS;

D O I：

10.1016/j.intimp.2023.109755

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rheumatoid arthritis (RA) is a multisystemic and inflammatory autoimmune disease characterized by joint destruction. The C-C motif chemokine receptor 2 (CCR2) is mainly expressed in monocytes and T cells, initiating their migration to sites of inflammation, ultimately leading to cartilage damage and bone destruction. CCR2 has long been considered a prospective target for treating autoimmune diseases. However, clinical studies on in-hibitors or neutralizing antibodies against CCR2 in RA have exhibited limited efficacy. Recent evidence indicates that CCR2 may play different roles in RA. Hence, a comprehensive understanding regarding the role of CCR2 may facilitate the development of targeted drugs and provide novel insights for improving CCL2-mediated inflam-matory diseases. This review summarizes the biological characteristics of CCR2, the related signaling pathways, and recent developments in CCR2-targeting therapeutics.

引用

页数：6