Role of chemokine receptor 2 in rheumatoid arthritis: A research update

被引：8
作者：
Chen, Weile [1 ]
Zhu, Xiangling [1 ]
Xu, Zhen [1 ]
Jiang, Haifeng [1 ]
Wu, Xuming [1 ]
Hong, Wenming [2 ]
Wang, Xinming [2 ]
Tu, Jiajie [1 ,3 ]
Wei, Wei [1 ,3 ]
机构：
[1] Anhui Med Univ, Inst Clin Pharmacol, Anhui Collaborat Innovat Ctr Antiinflammatory & Im, Key Lab Antiinflammatory & Immune Med,Minist Educ, Hefei, Peoples R China
[2] Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China
[3] 81 Meishan Rd, Hefei, Anhui, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2023年 / 116卷
基金：
中国国家自然科学基金;
关键词：
CCR2; CCL2; Rheumatoid arthritis; Rheumatoid arthritis -related cells; Therapeutic target; FIBROBLAST-LIKE SYNOVIOCYTES; COLLAGEN-INDUCED ARTHRITIS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; PRO-INFLAMMATORY CYTOKINES; ADJUVANT-INDUCED ARTHRITIS; OXIDATIVE STRESS; DISEASE-ACTIVITY; CCR2; EXPRESSION; CELLS;
D O I：
10.1016/j.intimp.2023.109755
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Rheumatoid arthritis (RA) is a multisystemic and inflammatory autoimmune disease characterized by joint destruction. The C-C motif chemokine receptor 2 (CCR2) is mainly expressed in monocytes and T cells, initiating their migration to sites of inflammation, ultimately leading to cartilage damage and bone destruction. CCR2 has long been considered a prospective target for treating autoimmune diseases. However, clinical studies on in-hibitors or neutralizing antibodies against CCR2 in RA have exhibited limited efficacy. Recent evidence indicates that CCR2 may play different roles in RA. Hence, a comprehensive understanding regarding the role of CCR2 may facilitate the development of targeted drugs and provide novel insights for improving CCL2-mediated inflam-matory diseases. This review summarizes the biological characteristics of CCR2, the related signaling pathways, and recent developments in CCR2-targeting therapeutics.
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页数：6
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