Synthesis, spectral, in vitro microbial and DNA cleavage studies of isatin bishydrozone metal complexes

被引：4
作者：
Sail, Bhushan S. [1 ,2 ]
Naik, Vinod H. [2 ]
Kamli, Majid Rasool [3 ,4 ]
Prasanna, B. M. [5 ]
机构：
[1] Shree Damodar Higher Secondary Sch Sci Comba Marga, Dept Chem, South Goa, India
[2] Viswesaraya Technol Univ Belagavi, KLSs Vishwanathrao Deshpande Inst Technol Haliyal, Dept Chem, Belgaum, India
[3] King Abdulaziz Univ, Fac Sci, Dept Biol Sci, Jeddah 21589, Saudi Arabia
[4] King Abdulaziz Univ, Ctr Excellence Bionanosci Res, Jeddah 21589, Saudi Arabia
[5] Viswesaraya Technol Univ Belagavi, Bapuji Inst Engn & Technol, Dept Chem, Davaagere 577004, India
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2023年 / 1277卷
关键词：
Antimicrobial; DNA; Spectroscopic; Transition metal complexes; Electrochemical; CU(II) COMPLEXES; SCHIFF-BASES; PHYSICOCHEMICAL INVESTIGATIONS; SPECTROSCOPIC CHARACTERIZATION; ELECTROCHEMICAL PROPERTIES; ANTIBACTERIAL ACTIVITY; ZN(II) COMPLEXES; NI(II); CO(II); COPPER(II);
D O I：
10.1016/j.molstruc.2022.134837
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
ONNO donor Schiff bases with recent group of Co(II), Ni(II), and Cu(II) complexes have been created and analyzed using spectroscopic research, thermal analysis, magnetic susceptibility, conductance tests, and elemental analysis. Via lactonyl oxygen and azomethine nitrogen, the Schiff bases are coordinated to the metal ion. In most common organic solvents, the complexes are insoluble but soluble in DMSO. The Co(II), Ni(II), and Cu(II) complexes' antibacterial properties, tested on quartet bacteria and two fungi strains showed an increased activity with respect to the Schiff bases. The Co(II), Ni(II) and Cu(II) complexes show more pronounced DNA cleaving activity. On cyclic voltammograms, the Cu(II) or Co(II) complexes tested in the DMSO solution showed metal-centered electro activity between 1.5 and + 1.5 V.(c) 2022 Elsevier B.V. All rights reserved.
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页数：9
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