Validation of the Nigerian Breast Cancer Study Model for Predicting Individual Breast Cancer Risk in Cameroon and Uganda

被引:3
作者
Ashi, Kevin [1 ]
Ndom, Paul [2 ]
Gakwaya, Antony [3 ]
Makumbi, Timothy [4 ]
Olopade, Olufunmilayo I. [5 ]
Huo, Dezheng [6 ,7 ]
机构
[1] Univ Chicago, Pritzker Sch Med, Chicago, IL USA
[2] Hop Gen Yaounde, Yaounde, Cameroon
[3] St Augustine Int Univ, Kampala, Uganda
[4] Mulago Hosp, Dept Surg, Kampala, Uganda
[5] Univ Chicago, Ctr Clin Canc Genet & Global Hlth, Dept Med, Chicago, IL 60637 USA
[6] Univ Chicago, Dept Publ Hlth Sci, Chicago, IL USA
[7] Univ Chicago, 5841 S Maryland Ave, Chicago, IL 60637 USA
关键词
WOMEN;
D O I
10.1158/1055-9965.EPI-22-0869
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The Nigerian Breast Cancer Study (NBCS) model is a new risk assessment tool developed for predicting risk of invasive breast cancer in Nigeria. Its applicability outside of Nigeria remains uncertain as it has not been validated in other sub-Saharan Africa populations.Methods: We conducted a case-control study among women with breast cancer and controls ascertained in Cameroon and Uganda from 2011 to 2016. Structured questionnaire interviews were performed to collect risk factor characteristics. The NBCS model, the Gail model, the Gail model for Black population, and the Black Women's Health Study model were applied to the Cameroon and Uganda samples separately. Nigerian as well as local incidence rates were incorporated into the models. Receiver-Operating Char-acteristic analyses were performed to indicate discriminating capacity.Results: The study included 550 cases (mean age 46.8 +/- 11.9) and 509 controls (mean age 46.3 +/- 11.7). Compared with the other three models, the NBCS model performed best in both countries. The discriminating accuracy of the NBCS model in Cameroon (age-adjusted C-index = 0.602; 95% CI, 0.542-0.661) was better than in Uganda (age-adjusted C-index = 0.531; 95% CI, 0.459-0.603). Conclusions: These findings demonstrate the potential clinical utility of the NBCS model for risk assessment in Cameroon. All currently available models performed poorly in Uganda, which suggests that the NBCS model may need further calibration before use in other regions of Africa.Impact: Differences in risk profiles across the African diaspora underscores the need for larger studies and may require develop-ment of region-specific risk assessment tools for breast cancer.
引用
收藏
页码:98 / 104
页数:7
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