Cartilage-targeting and inflammatory-responsive nanocarriers for effective osteoarthritis treatment via reactive oxygen species scavenging and anti-angiogenesis

被引:10
作者
Wang, Sixiang [1 ]
Gao, Yan [1 ]
Dong, Lili [2 ]
Chen, Peixing [3 ]
Liu, Wanqian [1 ]
Yang, Li [1 ]
机构
[1] Chongqing Univ, Coll Bioengn, Natl Innovat & Attracting Talents base 111, Key Lab Biorheol Sci & Technol Minist Educ, Chongqing 400030, Peoples R China
[2] Chongqing Med Univ, Dept Orthopaed, Affiliated Hosp 1, Chongqing 400042, Peoples R China
[3] Chongqing Univ Sci & Technol, Sch Met & Mat Engn, Chongqing Key Lab Nano Micro Composite Mat & Devic, Chongqing 401331, Peoples R China
来源
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY | 2023年 / 143卷
基金
中国国家自然科学基金;
关键词
Osteoarthritis; Reactive oxygen species; Angiogenesis; Cartilage-targeting; Drug delivery systems; Chitosan-catechol nanocarriers; CHONDROCYTE APOPTOSIS; ARTICULAR-CARTILAGE; N-ACETYLCYSTEINE; CHITOSAN; STRESS; INHIBITION; CELLS; DEGENERATION; NANOPARTICLES; SUPPRESSION;
D O I
10.1016/j.jmst.2022.08.048
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Osteoarthritis (OA), a common disabling joint disease, is highly associated with microenvironmental changes in the cartilage and subchondral bone. Elevated reactive oxygen species (ROS) in the cartilage and subchondral bone angiogenesis accelerate articular cartilage erosion. New cartilage-targeting drug deliv-ery systems that are aimed at preventing ROS production and angiogenesis may be of clinical significance for OA treatment. Herein, an ROS scavenger and an inflammatory-responsive nanocarrier are designed by immobilizing the natural polyphenol (curcumin) in chitosan-catechol nanoformulations (Cur-CS-C NPs) via boronate ester. The robust cartilage-targeting effects and ROS scavenging capacities of Cur-CS-C NPs were respectively determined in cartilage explants and chondrocytes. Intra-articular injection of Cur-CS-C NPs in OA rat models efficiently suppressed angiogenesis and cartilage degradation partially via the ROS-mediated NF-Kappa B/PI3K-Akt signaling pathway. The developed curcumin-functionalized nanocarriers can significantly delay OA progression and provide a promising therapeutic strategy for other inflamma-tory diseases that are characterized by oxidative stress and angiogenesis.(c) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
引用
收藏
页码:30 / 42
页数:13
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