Cartilage-targeting and inflammatory-responsive nanocarriers for effective osteoarthritis treatment via reactive oxygen species scavenging and anti-angiogenesis
被引:10
作者:
Wang, Sixiang
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机构:
Chongqing Univ, Coll Bioengn, Natl Innovat & Attracting Talents base 111, Key Lab Biorheol Sci & Technol Minist Educ, Chongqing 400030, Peoples R ChinaChongqing Univ, Coll Bioengn, Natl Innovat & Attracting Talents base 111, Key Lab Biorheol Sci & Technol Minist Educ, Chongqing 400030, Peoples R China
Wang, Sixiang
[1
]
Gao, Yan
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机构:
Chongqing Univ, Coll Bioengn, Natl Innovat & Attracting Talents base 111, Key Lab Biorheol Sci & Technol Minist Educ, Chongqing 400030, Peoples R ChinaChongqing Univ, Coll Bioengn, Natl Innovat & Attracting Talents base 111, Key Lab Biorheol Sci & Technol Minist Educ, Chongqing 400030, Peoples R China
Gao, Yan
[1
]
Dong, Lili
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机构:
Chongqing Med Univ, Dept Orthopaed, Affiliated Hosp 1, Chongqing 400042, Peoples R ChinaChongqing Univ, Coll Bioengn, Natl Innovat & Attracting Talents base 111, Key Lab Biorheol Sci & Technol Minist Educ, Chongqing 400030, Peoples R China
Dong, Lili
[2
]
Chen, Peixing
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机构:
Chongqing Univ Sci & Technol, Sch Met & Mat Engn, Chongqing Key Lab Nano Micro Composite Mat & Devic, Chongqing 401331, Peoples R ChinaChongqing Univ, Coll Bioengn, Natl Innovat & Attracting Talents base 111, Key Lab Biorheol Sci & Technol Minist Educ, Chongqing 400030, Peoples R China
Chen, Peixing
[3
]
Liu, Wanqian
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h-index: 0
机构:
Chongqing Univ, Coll Bioengn, Natl Innovat & Attracting Talents base 111, Key Lab Biorheol Sci & Technol Minist Educ, Chongqing 400030, Peoples R ChinaChongqing Univ, Coll Bioengn, Natl Innovat & Attracting Talents base 111, Key Lab Biorheol Sci & Technol Minist Educ, Chongqing 400030, Peoples R China
Liu, Wanqian
[1
]
Yang, Li
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Chongqing Univ, Coll Bioengn, Natl Innovat & Attracting Talents base 111, Key Lab Biorheol Sci & Technol Minist Educ, Chongqing 400030, Peoples R ChinaChongqing Univ, Coll Bioengn, Natl Innovat & Attracting Talents base 111, Key Lab Biorheol Sci & Technol Minist Educ, Chongqing 400030, Peoples R China
Yang, Li
[1
]
机构:
[1] Chongqing Univ, Coll Bioengn, Natl Innovat & Attracting Talents base 111, Key Lab Biorheol Sci & Technol Minist Educ, Chongqing 400030, Peoples R China
[2] Chongqing Med Univ, Dept Orthopaed, Affiliated Hosp 1, Chongqing 400042, Peoples R China
[3] Chongqing Univ Sci & Technol, Sch Met & Mat Engn, Chongqing Key Lab Nano Micro Composite Mat & Devic, Chongqing 401331, Peoples R China
来源:
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
|
2023年
/
143卷
Osteoarthritis (OA), a common disabling joint disease, is highly associated with microenvironmental changes in the cartilage and subchondral bone. Elevated reactive oxygen species (ROS) in the cartilage and subchondral bone angiogenesis accelerate articular cartilage erosion. New cartilage-targeting drug deliv-ery systems that are aimed at preventing ROS production and angiogenesis may be of clinical significance for OA treatment. Herein, an ROS scavenger and an inflammatory-responsive nanocarrier are designed by immobilizing the natural polyphenol (curcumin) in chitosan-catechol nanoformulations (Cur-CS-C NPs) via boronate ester. The robust cartilage-targeting effects and ROS scavenging capacities of Cur-CS-C NPs were respectively determined in cartilage explants and chondrocytes. Intra-articular injection of Cur-CS-C NPs in OA rat models efficiently suppressed angiogenesis and cartilage degradation partially via the ROS-mediated NF-Kappa B/PI3K-Akt signaling pathway. The developed curcumin-functionalized nanocarriers can significantly delay OA progression and provide a promising therapeutic strategy for other inflamma-tory diseases that are characterized by oxidative stress and angiogenesis.(c) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
机构:
Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
Jilin Univ, Sch Stomatol, Changchun 130021, Jilin, Peoples R ChinaChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
Bao, Xingfu
Zhao, Jiahui
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
Univ Chinese Acad Sci, Beijing 100049, Peoples R ChinaChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
Zhao, Jiahui
Sun, Jian
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R ChinaChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
Sun, Jian
Hu, Min
论文数: 0引用数: 0
h-index: 0
机构:
Jilin Univ, Sch Stomatol, Changchun 130021, Jilin, Peoples R ChinaChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
Hu, Min
Yang, Xiurong
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R ChinaChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
机构:
Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Kaohsiung Med Univ, Sch Med, Dept Biochem, Coll Med, Kaohsiung 80708, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Chiu, Pu-Rong
Hu, Yu-Chen
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Sch Med, Dept Biochem, Coll Med, Kaohsiung 80708, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Hu, Yu-Chen
Huang, Tzu-Ching
论文数: 0引用数: 0
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机构:
Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Kaohsiung Med Univ, Sch Med, Dept Biochem, Coll Med, Kaohsiung 80708, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Huang, Tzu-Ching
Hsieh, Bau-Shan
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Sch Med, Dept Biochem, Coll Med, Kaohsiung 80708, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Hsieh, Bau-Shan
Yeh, Jou-Pei
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Sch Med, Dept Biochem, Coll Med, Kaohsiung 80708, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Yeh, Jou-Pei
Cheng, Hsiao-Ling
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Pulm & Crit Care Med, Dept Internal Med, Kaohsiung 80756, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Cheng, Hsiao-Ling
Huang, Li-Wen
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol, Kaohsiung 80708, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Huang, Li-Wen
Chang, Kee-Lung
论文数: 0引用数: 0
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机构:
Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Kaohsiung Med Univ, Sch Med, Dept Biochem, Coll Med, Kaohsiung 80708, Taiwan
Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Coll Sci, Kaohsiung 80424, Taiwan
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 80756, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Chang, Kee-Lung
[J].
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,
2017,
18
(01):
机构:
Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
Jilin Univ, Sch Stomatol, Changchun 130021, Jilin, Peoples R ChinaChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
Bao, Xingfu
Zhao, Jiahui
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
Univ Chinese Acad Sci, Beijing 100049, Peoples R ChinaChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
Zhao, Jiahui
Sun, Jian
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R ChinaChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
Sun, Jian
Hu, Min
论文数: 0引用数: 0
h-index: 0
机构:
Jilin Univ, Sch Stomatol, Changchun 130021, Jilin, Peoples R ChinaChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
Hu, Min
Yang, Xiurong
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R ChinaChinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China
机构:
Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Kaohsiung Med Univ, Sch Med, Dept Biochem, Coll Med, Kaohsiung 80708, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Chiu, Pu-Rong
Hu, Yu-Chen
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Sch Med, Dept Biochem, Coll Med, Kaohsiung 80708, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Hu, Yu-Chen
Huang, Tzu-Ching
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Kaohsiung Med Univ, Sch Med, Dept Biochem, Coll Med, Kaohsiung 80708, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Huang, Tzu-Ching
Hsieh, Bau-Shan
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Sch Med, Dept Biochem, Coll Med, Kaohsiung 80708, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Hsieh, Bau-Shan
Yeh, Jou-Pei
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Sch Med, Dept Biochem, Coll Med, Kaohsiung 80708, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Yeh, Jou-Pei
Cheng, Hsiao-Ling
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Pulm & Crit Care Med, Dept Internal Med, Kaohsiung 80756, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Cheng, Hsiao-Ling
Huang, Li-Wen
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol, Kaohsiung 80708, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Huang, Li-Wen
Chang, Kee-Lung
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Kaohsiung Med Univ, Sch Med, Dept Biochem, Coll Med, Kaohsiung 80708, Taiwan
Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Coll Sci, Kaohsiung 80424, Taiwan
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 80756, TaiwanKaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 80708, Taiwan
Chang, Kee-Lung
[J].
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,
2017,
18
(01):