Protein intake, physical activity and grip strength in European and North American community-dwelling older adults: a pooled analysis of individual participant data from four longitudinal ageing cohorts

被引：6

作者：

Mendonca, Nuno M. P. ^{[1
,2
,3
,4
]}

Hengeveld, Linda M. ^{[4
,5
]}

Presse, Nancy ^{[6
,7
,8
]}

Canhao, Helena ^{[1
,2
]}

Simonsick, Eleanor ^{[9
]}

Kritchevsky, Stephen B. ^{[10
]}

Farsijani, Samaneh ^{[11
]}

Gaudreau, Pierrette ^{[12
,13
]}

Jagger, Carol ^{[3
]}

Visser, Marjolein ^{[4
]}

机构：

[1] Univ Nova Lisboa, NOVA Med Sch, EpiDoC Unit, Lisbon, Portugal

[2] Comprehens Hlth Res Ctr CHRC, Lisbon, Portugal

[3] Newcastle Univ, Populat Hlth Sci Inst, Newcastle Upon Tyne, Tyne & Wear, England

[4] Vrije Univ Amsterdam, Fac Sci, Amsterdam Publ Hlth Res Inst, Dept Hlth Sci, Amsterdam, Netherlands

[5] Hlth Council Netherlands, The Hague, Netherlands

[6] CIUSSS Estrie CHUS, Res Ctr Aging, Sherbrooke, PQ, Canada

[7] Univ Sherbrooke, Fac Med & Hlth Sci, Sherbrooke, PQ, Canada

[8] Ctr Rech Inst Univ Geriatrie Montreal, Montreal, PQ, Canada

[9] Natl Inst Aging Intramural Res Program, Baltimore, MD USA

[10] Wake Forest Sch Med, Sticht Ctr Aging, Winston Salem, NC 27101 USA

[11] Univ Pittsburgh, Ctr Aging & Populat Hlth, Dept Epidemiol, Pittsburgh, PA USA

[12] Univ Montreal, Dept Med, Montreal, PQ, Canada

[13] Univ Montreal Hosp Ctr, Res Ctr, Montreal, PQ, Canada

来源：

BRITISH JOURNAL OF NUTRITION | 2023年 / 129卷 / 07期

基金：

英国医学研究理事会; 欧盟地平线“2020”; 加拿大健康研究院;

关键词：

Protein; Handgrip strength; Physical activity; Joint models; PROMISS; Older adults; One-stage meta-analysis; DIETARY-PROTEIN; MUSCLE STRENGTH; PROSPECTIVE ASSOCIATIONS; FOOD SOURCES; HEALTH; ENERGY; RECOMMENDATIONS; QUESTIONNAIRE; DETERMINANT; PERFORMANCE;

D O I：

10.1017/S0007114522002033

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Higher dietary protein, alone or in combination with physical activity (PA), may slow the loss of age-related muscle strength in older adults. We investigated the longitudinal relationship between protein intake and grip strength, and the interaction between protein intake and PA, using four longitudinal ageing cohorts. Individual participant data from 5584 older adults (52 % women; median: 75 years, IQR: 71 center dot 6, 79 center dot 0) followed for up to 8 center dot 5 years (mean: 4 center dot 9 years, SD: 2 center dot 3) from the Health ABC, NuAge, LASA and Newcastle 85+ cohorts were pooled. Baseline protein intake was assessed with food frequency questionnaires and 24-h recalls and categorized into < 0 center dot 8, 0 center dot 8-<1 center dot 0, 1 center dot 0-<1 center dot 2 and >= 1 center dot 2 g/kg adjusted body weight (aBW)/d. The prospective association between protein intake, its interaction with PA, and grip strength (sex- and cohort-specific) was determined using joint models (hierarchical linear mixed effects and a link function for Cox proportional hazards models). Grip strength declined on average by 0 center dot 018 SD (95 % CI: -0 center dot 026, -0 center dot 006) every year. No associations were found between protein intake, measured at baseline, and grip strength, measured prospectively, or rate of decline of grip strength in models adjusted for sociodemographic, anthropometric, lifestyle and health variables (e.g., protein intake >= 1 center dot 2 v center dot < 0 center dot 8 g/kg aBW/d: beta = -0 center dot 003, 95 % CI: -0 center dot 014, 0 center dot 005 SD per year). There also was no evidence of an interaction between protein intake and PA. We failed to find evidence in this study to support the hypothesis that higher protein intake, alone or in combination with higher PA, slowed the rate of grip strength decline in older adults.

引用

页码：1221 / 1231

页数：11

共 57 条

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