Molecularly imprinted polymer paper-based analytical devices for biomarkers detection

被引:22
作者
Alahmad, Waleed [1 ]
Cetinkaya, Ahmet [2 ,3 ]
Kaya, S. Irem [4 ]
Varanusupakul, Pakorn [1 ]
Ozkan, Sibel A. [2 ]
机构
[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Bangkok, Thailand
[2] Ankara Univ, Fac Pharm, Dept Analyt Chem, Ankara, Turkiye
[3] Ankara Univ, Grad Sch Hlth Sci, Ankara, Turkiye
[4] Univ Hlth Sci, Gulhane Fac Pharm, Dept Analyt Chem, Ankara, Turkiye
关键词
Paper-based analytical devices; Molecularly imprinted polymers; Biomarker; Detection; SENSOR;
D O I
10.1016/j.trac.2023.117475
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Paper-based analytical devices (PADs), thanks to the versatility, cheapness, availability, biodegradability, and porosity of paper, have emerged as flexible sensing platforms for determining various analytes. However, lack of selectivity can be a problem in complex analysis conditions and samples. To improve the selectivity and specificity of PADs, they can be integrated with molecularly imprinted polymers (MIPs). The high selectivity of the sensor is the essential feature for biomarker analysis because the reliable and accurate determination of biomarkers provides valuable information about various diseases, especially cancer. Therefore, MIP-PAD systems offer a good option for biomarker analysis. This way, it is possible to achieve point-of-care tests, early diagnosis, and affordability. This review points out the significant processes of MIP-PAD fabrication and characterization (paper selection and fabrication, synthesis of MIP). The most recent applications of MIP-PADs for biological samples are explained and discussed in detail. Lastly, the commercialization of MIP-PADs is evaluated. This study is the first in the literature to assess MIP-PADs for biomarkers analysis.
引用
收藏
页数:15
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