High specificity THz metamaterial-based biosensor for label-free transcription factor detection in melanoma diagnostics

被引:6
作者
Richter, Merle [1 ]
Loth, Yannik [1 ]
Wigger, Anna Katharina [1 ]
Nordhoff, Daniela [1 ]
Rachinger, Nicole [2 ]
Weisenstein, Christian [1 ]
Bosserhoff, Anja Katrin [2 ]
Bolivar, Peter Haring [1 ]
机构
[1] Univ Siegen, High Frequency & Quantum Elect, D-57076 Siegen, Germany
[2] Friedrich Alexander Univ Erlangen Nurnberg FAU, Biochem & Mol Med, D-91054 Erlangen, Germany
关键词
TERAHERTZ; DNA; CANCER; CELLS;
D O I
10.1038/s41598-023-46876-5
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this work, we present a promising diagnostic tool for melanoma diagnosis. With the proposed terahertz biosensor, it was possible to selectively and sensitively detect the early growth response protein 2, a transcription factor with an increased activity in melanoma cells, from a complex sample of cellular proteins. Fundamentally, the sensor belongs to the frequency selective surface type metamaterials and consists of a two-dimensional array of asymmetrically, doubly split ring resonator unit cells. The single elements are slits in a metallic layer and are complemented by an undercut etch. This allows a selective functionalization of the active area of the sensor and increases the sensitivity towards the target analyte. Hereby, specific detection of a defined transcription factor is feasible.
引用
收藏
页数:11
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