Parathyroid Hormone Related Peptide Hypercalcemia as a Presentation of Endometrial Clear Cell Carcinoma

被引:0
作者
Georges, Claudia [1 ]
Adhikari, Biplov [1 ]
Koundaveety, Soumya [1 ]
Jones, Robert [2 ]
Paudel, Kalyan [3 ]
Haas, Christopher [4 ,5 ]
机构
[1] MedStar Union Mem Hosp, MedStar Hlth Internal Med Residency Program, Dept Med, Baltimore, MD 21218 USA
[2] Medstar Franklin Sq Med Ctr, Dept Pathol, Baltimore, MD USA
[3] MedStar Harbor Hosp, Dept Radiol, Baltimore, MD USA
[4] MedStar Franklin Sq Med Ctr, Dept Internal Med, Baltimore, MD USA
[5] Georgetown Univ, Med Ctr, Dept Med, Washington, DC USA
关键词
Hypercalcemia; Endometrial clear cell carcinoma; PTHrP; HHM; Humoral hypercalcemia of malignancy; CANCER; PROTEIN;
D O I
10.55729/2000-9666.1271
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hypercalcemia is a frequent complication of solid tumors and hematologic malignancies yet is only rarely associated with endometrial clear cell carcinoma. Here we report on a 70-year-old female who presented in the context of hip fracture and was incidentally found to have humoral hypercalcemia of malignancy secondary to endometrial clear cell carcinoma. This rare association makes endometrial cancer one of the differential diagnoses to be considered when assessing incidentally found symptomatic or asymptomatic hypercalcemia in the appropriate patient population.
引用
收藏
页码:67 / 70
页数:6
相关论文
共 17 条
[1]   The clinical utility of parathyroid hormone-related peptide in the assessment of hypercalcemia [J].
Fritchie, Karen ;
Zedek, Daniel ;
Grenache, David G. .
CLINICA CHIMICA ACTA, 2009, 402 (1-2) :146-149
[2]  
Gadducci A, 2010, ANTICANCER RES, V30, P1327
[3]   Prevalence of hypercalcemia among cancer patients in the United States [J].
Gastanaga, Victor M. ;
Schwartzberg, Lee S. ;
Jain, Rajul K. ;
Pirolli, Melissa ;
Quach, David ;
Quigley, Jane M. ;
Mu, George ;
Stryker, W. Scott ;
Liede, Alexander .
CANCER MEDICINE, 2016, 5 (08) :2091-2100
[4]   Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis [J].
Guise, TA ;
Yin, JJ ;
Taylor, SD ;
Kumagai, Y ;
Dallas, M ;
Boyce, BF ;
Yoneda, T ;
Mundy, GR .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (07) :1544-1549
[5]   Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers [J].
Hamilton, CA ;
Cheung, MK ;
Osann, K ;
Chen, L ;
Teng, NN ;
Longacre, TA ;
Powell, MA ;
Hendrickson, MR ;
Kapp, DS ;
Chan, JK .
BRITISH JOURNAL OF CANCER, 2006, 94 (05) :642-646
[6]   Endometrial clear cell carcinoma invading the right oviduct with a cooccurring ipsilateral oviduct adenomatoid tumor: A case report [J].
Hu, Zhi-Xiong ;
Tan, Min-Hua ;
Li, Qiong-Zhen ;
Xu, Jia-Li ;
Chen, Wei ;
Xie, Zhi-Hao ;
Zhou, Yong-Jian ;
Liang, Qing ;
An, Jian-Hong ;
Shen, Hong .
WORLD JOURNAL OF CLINICAL ONCOLOGY, 2020, 11 (12) :1076-+
[7]  
Jin Joon, 2017, J Bone Metab, V24, P249, DOI [10.11005/jbm.2017.24.4.249, 10.11005/jbm.2017.24.4.249]
[8]   Lenvatinib plus Pembrolizumab for Advanced Endometrial Cancer [J].
Makker, V ;
Colombo, N. ;
Casado Herraez, A. ;
Santin, A. D. ;
Colomba, E. ;
Miller, D. S. ;
Fujiwara, K. ;
Pignata, S. ;
Baron-Hay, S. ;
Ray-Coquard, I ;
Shapira-Frommer, R. ;
Ushijima, K. ;
Sakata, J. ;
Yonemori, K. ;
Kim, Y. M. ;
Guerra, E. M. ;
Sanli, U. A. ;
McCormack, M. M. ;
Smith, A. D. ;
Keefe, S. ;
Bird, S. ;
Dutta, L. ;
Orlowski, R. J. ;
Lorusso, D. .
NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (05) :437-448
[9]  
Nehru VM, 2017, AM J CASE REP, V18, P22, DOI 10.12659/AJCR.900088
[10]   Safety and Antitumor Activity of Pembrolizumab in Advanced Programmed Death Ligand 1-Positive Endometrial Cancer: Results From the KEYNOTE-028 Study [J].
Ott, Patrick A. ;
Bang, Yung-Jue ;
Berton-Rigaud, Dominique ;
Elez, Elena ;
Pishvaian, Michael J. ;
Rugo, Hope S. ;
Puzanov, Igor ;
Mehnert, Janice M. ;
Aung, Kyaw L. ;
Lopez, Juanita ;
Carrigan, Marion ;
Saraf, Sanatan ;
Chen, Mei ;
Soria, Jean-Charles .
JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (22) :2535-+