Potentially inappropriate medications and polypharmacy in the older population: A nationwide cross-sectional study in France in 2019

Aim of the study. - To assess the prevalence of potentially inappropriate medications (PIMs) and polypharmacy in adults aged 75 years and over in France in 2019 based on data from the French health insurance claims database, at the national level and by region. Methods. - We conducted a cross-sectional study in French adults aged 75 years or over in 2019. We assessed the prevalence of seventeen PIM criteria adapted from the 2015 Beers and STOPP lists, as well as cumulative polypharmacy. Polypharmacy (5 to 9 drugs) and hyper-polypharmacy (>= 10 drugs) were defined as the average number of drugs dispensed per quarter. The regional analysis used the age-and sex-standardized prevalence. Results. - Of 6,707,897 older adults, 39.6% were exposed to at least one PIM in 2019, 46.7% were exposed to polypharmacy (5 to 9 drugs), and 25.2% to hyper-polypharmacy (>= 10 drugs). Benzodiazepine PIMs were the most frequent (26.9%), followed by atropinic PIMs (8.3%), non-steroidal anti-inflammatory PIMs (7.8%), concomitant use of three or more central nervoussystemactive drugs (7.3%), and antihypertensive PIMs (6.0%). There was a gradient in the levelof exposure to PIMs according to the level of polypharmacy for every PIM category. We observed regional variations in PIM prevalence, from 36.5% in Pays-de-la-Loire to 44.8% in Hauts-de-France in mainland France. Conclusion. - These results show that PIMs concerned more than one in three older adults after age 75 years in France in 2019 and support the need to secure medication use in this population. The reasons for geographic variations in PIM prevalence should be investigated in further studies. (c) 2023 L'Auteur(s). Publi ' e par Elsevier Masson SAS au nom de Soci ' et ' e francaise de pharmacologie et de th ' erapeutique. Cet article est publi ' e en Open Access sous licence CC BYNC-ND (http://creativecommons.org/licenses/by-nc-nd/4.0/).