Recent Developments in Blood Biomarkers in Neuro-oncology

被引：4

作者：

Foster, Jessica B. ^{[1
]}

Koptyra, Mateusz P. ^{[2
]}

Bagley, Stephen J. ^{[3
]}

机构：

[1] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Oncol, Philadelphia, PA USA

[2] Childrens Hosp Philadelphia, Ctr Data Driven Discovery Biomed D3b, Philadelphia, PA USA

[3] Univ Penn, Hosp Univ Penn, Perelman Sch Med, Div Hematol Oncol, 10 Floor Perelman Ctr,3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA

来源：

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2023年 / 23卷 / 12期

关键词：

Biomarkers; Neuro-Oncology; Liquid Biopsy; cfDNA; Glioma; Blood; PLASMA; RNA; GLIOBLASTOMA; DNA; CELLS;

D O I：

10.1007/s11910-023-01321-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose of ReviewGiven the invasive and high-risk nature of brain surgery, the need for non-invasive biomarkers obtained from the peripheral blood is greatest in tumors of the central nervous system (CNS). In this comprehensive review, we highlight recent advances in blood biomarker development for adult and pediatric brain tumors.Recent FindingsWe summarize recent blood biomarker development for CNS tumors across multiple key analytes, including peripheral blood mononuclear cells, cell-free DNA, cell-free RNA, proteomics, circulating tumor cells, and tumor-educated platelets. We also discuss methods for enhancing blood biomarker detection through transient opening of the blood-brain barrier.SummaryAlthough blood-based biomarkers are not yet used in routine neuro-oncology practice, this field is advancing rapidly and holds great promise for improved and non-invasive management of patients with brain tumors. Prospective and adequately powered studies are needed to confirm the clinical utility of any blood biomarker prior to widespread clinical implementation.

引用

页码：857 / 867

页数：11

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