Radiation nephropathy is associated with a glomerular thrombotic microangiopathy and progression to end-stage kidney disease

被引:0
作者
Bertoni, Isabela [1 ]
Soares, Maria F. [2 ]
Roberts, Ian S. D. [2 ]
Connor, Thomas [1 ]
机构
[1] Oxford Univ Hosp NHS Fdn Trust, Oxford Kidney Unit, Oxford, England
[2] Oxford Univ Hosp NHS Fdn Trust, Dept Cellular Pathol, Oxford, England
关键词
end-stage kidney disease; radiation injuries; thrombotic microangiopathies; THERAPY;
D O I
10.1093/ckj/sfad133
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Radiation nephropathy is a rare complication following total body irradiation (TBI) and peptide receptor radionuclide therapy (PRRT). Yttrium 90-DOTATOC (Y90) is a somatostatin analogue labelled with Y90 used for somatostatin-positive neuroendocrine tumours. Y90 is renally excreted and has a cumulative effect in the renal parenchyma Despite fractionation and co-administration of renoprotective intravenous amino acids, targeted radionuclide therapy can still be nephrotoxic. Rising adoption of PRRT has led to the re-emergence of radiation nephropathy. We report on three recent cases of insidious onset of progressive kidney dysfunction and biopsy-proven thrombotic microangiopathy following PRRT and TBI.
引用
收藏
页码:1534 / 1537
页数:4
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