α2C-Adrenergic Receptor Blockade Inhibits Langendorff-Isolated Rat Heart Work

被引：0
作者：
Zefirov, T. L. [1 ]
Khisamieva, L. I. [1 ]
Khabibrakhmanov, I. I. [1 ]
Ziyatdinova, N. I. [1 ]
Zefirov, A. L. [2 ]
机构：
[1] Kazan Volga Reg Fed Univ, Dept Human Hlth Protect, Kazan, Russia
[2] Kazan State Med Univ, Dept Normal Physiol, Minist Hlth Russian Federat, Kazan, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 175卷 / 5期
关键词：
heart; alpha(2C)-adrenergic receptor; myocardium; JP-1302; rat; CATECHOLAMINE RELEASE; IMIDAZOLINE RECEPTORS; SELECTIVE BLOCKADE; ALPHA(2)-ADRENOCEPTOR;
D O I：
10.1007/s10517-023-05911-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of selective alpha(2C)-adrenergic receptor antagonist JP-1302 in concentrations of 10(-9)-10(-6) M on inotropy, chronotropy, and coronary flow in the Langendorff-isolated rat heart. JP-1302 in all studied concentrations decreased the left-ventricular myocardium force contraction, HR, and coronary flow. The maximum inotropic, chronotropic, and vascular effects were observed when the antagonist was applied to the perfused solution in a concentration of 10(-7) M. The least pronounced decrease in the studied parameters was observed at JP-1302 concentrations of 10(-8) and 10(-9) M. The obtained data indicate the participation of this subtype of alpha(2)-adrenergic receptors in the regulation of activity of isolated adult rats heart.
引用
收藏
页码：612 / 615
页数：4
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