ET-traps: Potential therapeutics for preeclampsia

被引：4

作者：

Jain, Arjun ^{[1
,2
,3
,4
]}

Jain, Ira ^{[1
,5
,6
]}

机构：

[1] ET Traps, Cambridge CB3 0JE, England

[2] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge, England

[3] Univ Cambridge, Judge Business Sch, Accelerate Cambridge, Cambridge, England

[4] Imperial Coll London, London, England

[5] Indian Inst Management, Ahmadabad, India

[6] Natl Univ Singapore, Singapore, Singapore

来源：

DRUG DISCOVERY TODAY | 2023年 / 28卷 / 11期

关键词：

endothelin-1; preeclampsia; ER stress; oxidative stress; cardiovascular complications; proteinuria; ET-traps; ENDOTHELIN-1; TRAPS; IN-VIVO; HYPERTENSION; RECEPTOR; PATHOPHYSIOLOGY; STRESS; GROWTH; MODEL;

D O I：

10.1016/j.drudis.2023.103787

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Elevated endothelin-1 (ET-1) has been implicated in several diseases including preeclampsia, where it causes the induction of hypertension, oxidative stress, endoplasmic reticulum stress, microvascular dysfunction and tissue damage in different organs. ET-traps are Fc-fusion proteins with a design based on the physiological receptors of ET-1. This paper discusses the potential use of ET-traps as a therapeutic for preeclampsia. ET-traps potently bind and sequester pathologically elevated ET-1 to significantly reduce different markers of pathology to non-disease levels with no toxicity.

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页数：6

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