Current Perspectives and Future Prospects of mRNA Vaccines against Viral Diseases: A Brief Review

被引：4

作者：

Koppu, Vasavi ^{[1
]}

Poloju, Deepa ^{[1
]}

Puvvala, Bhavani ^{[1
]}

Madineni, Kavitha ^{[1
]}

Balaji, Shilpa ^{[1
]}

Sheela, Chandana Muraleedharan Pillai ^{[1
]}

Manchikanti, Sri Sai Charan ^{[1
]}

Moon, Satpathy Moon ^{[1
]}

机构：

[1] ICAR IVRI, Dept Vet Microbiol, Bareilly, Uttar Pradesh, India

来源：

INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE | 2023年 / 11卷 / 03期

关键词：

mRNA; vaccine; virus; lipid nanoparticle; codon optimization; LIPID NANOPARTICLES; IN-VIVO; DELIVERY; CELLS;

D O I：

10.22088/IJMCM.BUMS.11.3.260

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The mRNA vaccines replace our conventional vaccines (live-attenuated and inactivated vaccines) due to their high safety, efficacy, potency and low cost for their manufacturing. Since these many years, the use of these mRNA vaccines has been restricted as they are unstable and their low efficiency in in-vivo delivery. But now, these problems have been solved by recent technological advances. Many studies conducted in animal models and humans demonstrated the good results for the mRNA vaccines. This review provides you a detailed overview of mRNA viral vaccines and considers the current perspectives and future prospects.

引用

页码：260 / 272

页数：13

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