Left atrial strain and ventricular global longitudinal strain in cirrhotic patients using the new criteria of Cirrhotic Cardiomyopathy Consortium

被引:9
作者
Skouloudi, Marina [1 ]
Bonou, Maria S. [1 ]
Adamantou, Magdalini [2 ]
Parastatidou, Despoina [3 ]
Kapelios, Christos [1 ]
Masoura, Konstantina [1 ]
Efstathopoulos, Efstathios [4 ]
Aggeli, Constantina [5 ]
Papatheodoridis, George V. [3 ]
Barbetseas, John [1 ]
Cholongitas, Evangelos [2 ]
机构
[1] Gen Hosp Athens Laiko, Dept Cardiol, Athens, Greece
[2] Natl & Kapodistrian Univ Athens, Gen Hosp Athens Laiko, Med Sch, Dept Internal Med 1, Agiou Thoma 17, Athens 11527, Greece
[3] Natl & Kapodistrian Univ Athens, Gen Hosp Athens Laiko, Med Sch, Dept Gastroenterol, Athens, Greece
[4] Natl & Kapodistrian Univ Athens, Med Sch, Dept Radiol 2, Athens, Greece
[5] Natl & Kapodistrian Univ Athens, Gen Hosp Athens Hippokrat, Dept Cardiol 1, Sch Med, Athens, Greece
关键词
cirrhotic cardiomyopathy; end-stage liver disease; left atrial strain; left ventricular global longitudinal strain; visceral fat; DIASTOLIC DYSFUNCTION; SYSTOLIC DYSFUNCTION; EUROPEAN ASSOCIATION; NATRIURETIC PEPTIDE; AMERICAN SOCIETY; CARDIAC-FUNCTION; LIVER-CIRRHOSIS; ECHOCARDIOGRAPHY; RECOMMENDATIONS; PROGNOSIS;
D O I
10.1111/liv.15714
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: The new criteria of Cirrhotic Cardiomyopathy Consortium (CCC) propose the use of left ventricular global longitudinal strain (LV- GLS) for evaluation of systolic function in patients with cirrhosis. The aim of this study was to evaluate LV-GLS and left atrial (LA) strain in association with the severity of liver disease and to assess the characteristics of cirrhotic cardiomyopathy (CCM). Methods: One hundred and thirty-five cirrhotic patients were included. Standard echocardiography and speckle tracking echocardiography (2D-STE) were performed, and dual X-ray absorptiometry was used to quantify the total and regional fat mass. CCM was defined, based on the criteria of CCC, as having advanced diastolic dysfunction, left ventricular ejection fraction =50% and/or a GLS <18%. Results: LV-GLS lower or higher than the absolute mean value (22.7%) was not associated with mortality (logrank, p = 0.96). LV- GLS was higher in patients with Model for end stage liver disease (MELD) score =15 compared to MELD score <15 (p = 0.004). MELD score was the only factor independently associated with systolic function (LV-GLS <22.7% vs. =22.7%) (Odds Ratio:1.141, p = 0.032). Patients with CCM (n = 11) had higher values of estimated volume of visceral adipose tissue compared with patients without CCM (median: 735 vs. 641 cm3, p = 0.039). On multivariable Cox regression analysis, MELD score [Hazard Ratio (HR):1.26, p < 0.001] and LA reservoir strain (HR: 0.96, p = 0.017) were the only factors independently associated with the outcome. Conclusion: In our study, absolute LV-GLS was higher in more severe liver disease, and LA reservoir strain was significantly associated with the outcome in patients with end-stage liver disease.
引用
收藏
页码:2727 / 2742
页数:16
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