Fusarium-Derived Secondary Metabolites with Antimicrobial Effects

被引：25

作者：

Xu, Meijie ^{[1
]}

Huang, Ziwei ^{[1
]}

Zhu, Wangjie ^{[1
]}

Liu, Yuanyuan ^{[1
]}

Bai, Xuelian ^{[2
]}

Zhang, Huawei ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Sch Pharmaceut Sci, Hangzhou 310014, Peoples R China

[2] Hangzhou Normal Univ, Coll Life & Environm Sci, Hangzhou 311121, Peoples R China

来源：

MOLECULES | 2023年 / 28卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Fusarium; secondary metabolite; antimicrobial effect; antibacterial; antifungal; antiviral; antiparasitic; ENDOPHYTIC FUNGUS; ANTIBACTERIAL ACTIVITY; STRUCTURE ELUCIDATION; CHEMICAL-CONSTITUENTS; MARINE; ANTIFUNGAL; ACID; ENNIATINS; SOLANI; PAPULACANDIN;

D O I：

10.3390/molecules28083424

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fungal microbes are important in the creation of new drugs, given their unique genetic and metabolic diversity. As one of the most commonly found fungi in nature, Fusarium spp. has been well regarded as a prolific source of secondary metabolites (SMs) with diverse chemical structures and a broad spectrum of biological properties. However, little information is available concerning their derived SMs with antimicrobial effects. By extensive literature search and data analysis, as many as 185 antimicrobial natural products as SMs had been discovered from Fusarium strains by the end of 2022. This review first provides a comprehensive analysis of these substances in terms of various antimicrobial effects, including antibacterial, antifungal, antiviral, and antiparasitic. Future prospects for the efficient discovery of new bioactive SMs from Fusarium strains are also proposed.

引用

页数：15

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