Deciphering breast cancer: from biology to the clinic

被引：380

作者：

Nolan, Emma ^{[1
]}

Lindeman, Geoffrey J. ^{[2
,3
,4
]}

Visvader, Jane E. ^{[2
,5
]}

机构：

[1] Univ Auckland, Auckland Canc Soc Res Ctr, Auckland 1023, New Zealand

[2] Walter & Eliza Hall Inst Med Res, ACRF Canc Biol & Stem Cells Div, Parkville, Vic 3052, Australia

[3] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Parkville, Vic 3050, Australia

[4] Peter MacCallum Canc Ctr, Dept Med Oncol, Melbourne, Vic 3000, Australia

[5] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia

来源：

CELL | 2023年 / 186卷 / 08期

基金：

英国医学研究理事会;

关键词：

TUMOR-IMMUNE MICROENVIRONMENT; TRASTUZUMAB EMTANSINE; SINGLE-CELL; MOLECULAR PORTRAITS; TREATMENT DECISIONS; ESTROGEN-RECEPTOR; 70-GENE SIGNATURE; FREE SURVIVAL; DOUBLE-BLIND; PLUS;

D O I：

10.1016/j.cell.2023.01.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer remains a leading cause of cancer-related mortality in women, reflecting profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last decade, genomic and transcriptomic data have been integrated on an unprecedented scale and revealed distinct cancer subtypes, critical molecular drivers, clonal evolutionary trajectories, and prognostic signatures. Furthermore, multi-dimensional integration of high-resolution single-cell and spatial technologies has highlighted the importance of the entire breast cancer ecosystem and the presence of distinct cellular "neighborhoods."Clinically, a plethora of new targeted therapies has emerged, now being rapidly incorporated into routine care. Resistance to therapy, however, remains a crucial challenge for the field.

引用

页码：1708 / 1728

页数：21

共 140 条

[1] Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth [J].

Agus, DB ;

Akita, RW ;

Fox, WD ;

Lewis, GD ;

Higgins, B ;

Pisacane, PI ;

Lofgren, JA ;

Tindell, C ;

Evans, DP ;

Maiese, K ;

Scher, HI ;

Sliwkowski, MX .

CANCER CELL, 2002, 2 (02) :127-137

[2] Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer [J].

Ali, H. Raza ;

Jackson, Hartland W. ;

Zanotelli, Vito R. T. ;

Danenberg, Esther ;

Fischer, Jana R. ;

Bardwell, Helen ;

Provenzano, Elena ;

Rueda, Oscar M. ;

Chin, Suet-Feung ;

Aparicio, Samuel ;

Caldas, Carlos ;

Bodenmiller, Bernd .

NATURE CANCER, 2020, 1 (02) :163-+

[3] Spatial deconvolution of HER2-positive breast cancer delineates tumor-associated cell type interactions [J].

Andersson, Alma ;

Larsson, Ludvig ;

Stenbeck, Linnea ;

Salmen, Fredrik ;

Ehinger, Anna ;

Wu, Sunny Z. ;

Al-Eryani, Ghamdan ;

Roden, Daniel ;

Swarbrick, Alex ;

Borg, Ake ;

Frisen, Jonas ;

Engblom, Camilla ;

Lundeberg, Joakim .

NATURE COMMUNICATIONS, 2021, 12 (01)

[4] Biomarkers for Adjuvant Endocrine and Chemotherapy in Early-Stage Breast Cancer: ASCO Guideline Update [J].

Andre, Fabrice ;

Ismaila, Nofisat ;

Allison, Kimberly H. ;

Barlow, William E. ;

Collyar, Deborah E. ;

Damodaran, Senthil ;

Henry, N. Lynn ;

Jhaveri, Komal ;

Kalinsky, Kevin ;

Kuderer, Nicole M. ;

Litvak, Anya ;

Mayer, Erica L. ;

Pusztai, Lajos ;

Raab, Rachel ;

Wolff, Antonio C. ;

Stearns, Vered .

JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16) :1816-+

[5] Alpelisib for PIK3CA-Mutated, Hormone Receptor-Positive Advanced Breast Cancer [J].

Andre, Fabrice ;

Ciruelos, Eva ;

Rubovszky, Gabor ;

Campone, Mario ;

Loibl, Sibylle ;

Rugo, Hope S. ;

Iwata, Hiroji ;

Conte, Pierfranco ;

Mayer, Ingrid A. ;

Kaufman, Bella ;

Yamashita, Toshinari ;

Lu, Yen-Shen ;

Inoue, Kenichi ;

Takahashi, Masato ;

Papai, Zsuzsanna ;

Longin, Anne-Sophie ;

Mills, David ;

Wilke, Celine ;

Hirawat, Samit ;

Juric, Dejan .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (20) :1929-1940

[6] The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies [J].

Angus, Lindsay ;

Smid, Marcel ;

Wilting, Saskia M. ;

van Riet, Job ;

Van Hoeck, Arne ;

Luan Nguyen ;

Nik-Zainal, Serena ;

Steenbruggen, Tessa G. ;

Tjan-Heijnen, Vivianne C. G. ;

Labots, Mariette ;

van Riel, Johanna M. G. H. ;

Bloemendal, Haiko J. ;

Steeghs, Neeltje ;

Lolkema, Martijn P. ;

Voest, Emile E. ;

van de Werken, Harmen J. G. ;

Jager, Agnes ;

Cuppen, Edwin ;

Sleijfer, Stefan ;

Martens, John W. M. .

NATURE GENETICS, 2019, 51 (10) :1450-+

[7] Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment [J].

Azizi, Elham ;

Carr, Ambrose J. ;

Plitas, George ;

Cornish, Andrew E. ;

Konopacki, Catherine ;

Prabhakaran, Sandhya ;

Nainys, Juozas ;

Wu, Kenmin ;

Kiseliovas, Vaidotas ;

Setty, Manu ;

Choi, Kristy ;

Fromme, Rachel M. ;

Phuong Dao ;

McKenney, Peter T. ;

Wasti, Ruby C. ;

Kadaveru, Krishna ;

Mazutis, Linas ;

Rudensky, Alexander Y. ;

Pe'er, Dana .

CELL, 2018, 174 (05) :1293-+

[8] Sequence analysis of mutations and translocations across breast cancer subtypes [J].

Banerji, Shantanu ;

Cibulskis, Kristian ;

Rangel-Escareno, Claudia ;

Brown, Kristin K. ;

Carter, Scott L. ;

Frederick, Abbie M. ;

Lawrence, Michael S. ;

Sivachenko, Andrey Y. ;

Sougnez, Carrie ;

Zou, Lihua ;

Cortes, Maria L. ;

Fernandez-Lopez, Juan C. ;

Peng, Shouyong ;

Ardlie, Kristin G. ;

Auclair, Daniel ;

Bautista-Pina, Veronica ;

Duke, Fujiko ;

Francis, Joshua ;

Jung, Joonil ;

Maffuz-Aziz, Antonio ;

Onofrio, Robert C. ;

Parkin, Melissa ;

Pho, Nam H. ;

Quintanar-Jurado, Valeria ;

Ramos, Alex H. ;

Rebollar-Vega, Rosa ;

Rodriguez-Cuevas, Sergio ;

Romero-Cordoba, Sandra L. ;

Schumacher, Steven E. ;

Stransky, Nicolas ;

Thompson, Kristin M. ;

Uribe-Figueroa, Laura ;

Baselga, Jose ;

Beroukhim, Rameen ;

Polyak, Kornelia ;

Sgroi, Dennis C. ;

Richardson, Andrea L. ;

Jimenez-Sanchez, Gerardo ;

Lander, Eric S. ;

Gabriel, Stacey B. ;

Garraway, Levi A. ;

Golub, Todd R. ;

Melendez-Zajgla, Jorge ;

Toker, Alex ;

Getz, Gad ;

Hidalgo-Miranda, Alfredo ;

Meyerson, Matthew .

NATURE, 2012, 486 (7403) :405-409

[9] Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer [J].

Bardia, A. ;

Hurvitz, S. A. ;

Tolaney, S. M. ;

Loirat, D. ;

Punie, K. ;

Oliveira, M. ;

Brufsky, A. ;

Sardesai, S. D. ;

Kalinsky, K. ;

Zelnak, A. B. ;

Weaver, R. ;

Traina, T. ;

Dalenc, F. ;

Aftimos, P. ;

Lynce, F. ;

Diab, S. ;

Cortes, J. ;

O'Shaughnessy, J. ;

Dieras, V ;

Ferrario, C. ;

Schmid, P. ;

Carey, L. A. ;

Gianni, L. ;

Piccart, M. J. ;

Loibl, S. ;

Goldenberg, D. M. ;

Hong, Q. ;

Olivo, M. S. ;

Itri, L. M. ;

Rugo, H. S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (16) :1529-1541

[10] Unravelling triple-negative breast cancer molecular heterogeneity using an integrative multiomic analysis [J].

Bareche, Y. ;

Venet, D. ;

Ignatiadis, M. ;

Aftimos, P. ;

Piccart, M. ;

Rothe, F. ;

Sotiriou, C. .

ANNALS OF ONCOLOGY, 2018, 29 (04) :895-902

← 1 2 3 4 5 6 7 8 9 10 →