Immune checkpoints expression patterns in early-stage triple-negative breast cancer predict prognosis and remodel the tumor immune microenvironment

被引:3
作者
Zhang, Jinguo [1 ,2 ]
Jin, Hongwei [1 ,2 ,3 ]
Pan, Shuaikang [1 ,4 ]
Han, Chaoqiang [1 ]
Sun, Qingqing [1 ,2 ,3 ]
Han, Xinghua [1 ,2 ,3 ]
机构
[1] Anhui Med Univ, Dept Med Oncol, Anhui Prov Hosp, Hefei, Peoples R China
[2] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Med Oncol, Div Life Sci & Med, Hefei, Peoples R China
[3] Anhui Med Univ, Sch Med Oncol, Hefei, Peoples R China
[4] Wan Nan Med Coll, Sch Med Oncol, Wuhu, Peoples R China
基金
中国博士后科学基金;
关键词
triple-negative breast cancer; immune checkpoint genes; molecular subtypes; prognosis; nomogram; INFILTRATING LYMPHOCYTES; IDENTIFICATION; SUPPRESSION; SURVIVAL; CELLS;
D O I
10.3389/fimmu.2023.1073550
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
BackgroundCurrently, targeting immune checkpoint molecules holds great promise for triple-negative breast cancer (TNBC). However, the expression landscape of immune checkpoint genes (ICGs) in TNBC remains largely unknown. MethodHerein, we systematically investigated the ICGs expression patterns in 422 TNBC samples. We evaluated the ICGs molecular typing based on the ICGs expression profile and explored the associations between ICGs molecular subtypes and tumor immune characteristics, clinical significance, and response to immune checkpoint inhibitors (ICIs). ResultsTwo ICGs clusters and two ICGs-related gene clusters were determined, which were involved in different survival outcomes, biological roles and infiltration levels of immune cells. We established a quantification system ICGs riskscore (named IRS) to assess the ICGs expression patterns for individuals. TNBC patients with lower IRS were characterized by increased immune cell infiltration, favorable clinical outcomes and high sensitivity to ICIs therapy. We also developed a nomogram model combining clinicopathological variables to predict overall survival in TNBC. Genomic feature analysis revealed that high IRS group presented an increased tumor mutation burden compared with the low IRS group. ConclusionCollectively, dissecting the ICGs expression patterns not only provides a new insight into TNBC subtypes but also deepens the understanding of ICGs in the tumor immune microenvironment.
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收藏
页数:14
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